Sarabyar Sara, Farahbakhsh Afshin, Tahmasebi Hamzeh Ali, Mahmoodzadeh Vaziri Behrooz, Khosroyar Susan
Department of Chemical Engineering, Quchan Branch, Islamic Azad University, Quchan, Iran.
Sci Rep. 2024 Nov 9;14(1):27390. doi: 10.1038/s41598-024-73888-6.
This study delves into the development and optimization of photocatalysts, namely ZnO NPs/Zeolite and TiO NPs/Zeolite, for the degradation of two beta-blocker drugs, including Atenolol (AT) and Metoprolol (ME). Structural and morphological analyses of the catalysts were conducted, and optimal conditions for drug degradation were determined using a Box-Behnken design. The results underscored the significant influence of pH, catalyst amount, drug concentration, and HO concentration on the degradation process using ZnO NPs/Zeolite and TiO NPs/Zeolite as the catalysts. The optimal values of drug concentration, pH, catalyst amount, and HO concentration, were determined to be 32 and 33 mg L, 4.2 and 4.6, 428 and 386 mg, and 2.6 and 2.5 mM utilizing ZnO NPs/Zeolite and TiO NPs/Zeolite as the catalyst, respectively. Following optimization, the kinetics of the photodegradation process were investigated, revealing promising rates and half-life times for both drugs. The pseudo-first-order rate constants for Atenolol and Metoprolol degradation were 0.064 ± 0.007 min and 0.065 ± 0.004 min with ZnO NPs/Zeolite and 0.071 ± 0.007 min and 0.071 ± 0.006 min with TiO NPs/Zeolite, respectively. Furthermore, ZnO NPs/Zeolite and TiO NPs/Zeolite demonstrated reusability up to 5 and 6 times, respectively, without significant activity loss. The comparative analysis highlighted the superior performance of TiO NPs/Zeolite over ZnO NPs/Zeolite, attributed to lower consumption, shorter degradation time, improved reusability, and compatibility with milder acidic conditions. Overall, the research showcases the potential of ZnO NPs/Zeolite and TiO NPs/Zeolite as an effective and sustainable solution for removing Metoprolol and Atenolol contaminants.
本研究深入探讨了用于降解两种β受体阻滞剂药物（阿替洛尔（AT）和美托洛尔（ME））的光催化剂，即氧化锌纳米颗粒/沸石和二氧化钛纳米颗粒/沸石的开发与优化。对催化剂进行了结构和形态分析，并使用Box-Behnken设计确定了药物降解的最佳条件。结果强调了pH值、催化剂量、药物浓度和羟基自由基浓度对以氧化锌纳米颗粒/沸石和二氧化钛纳米颗粒/沸石为催化剂的降解过程的显著影响。以氧化锌纳米颗粒/沸石和二氧化钛纳米颗粒/沸石为催化剂时，药物浓度、pH值、催化剂量和羟基自由基浓度的最佳值分别确定为32和33毫克/升、4.2和4.6、428和386毫克以及2.6和2.5毫摩尔。优化后，研究了光降解过程的动力学，两种药物均显示出可观的降解速率和半衰期。阿替洛尔和美托洛尔降解的伪一级速率常数分别为：使用氧化锌纳米颗粒/沸石时为0.064±0.007分钟和0.065±0.004分钟，使用二氧化钛纳米颗粒/沸石时为0.071±0.007分钟和0.071±0.006分钟。此外，氧化锌纳米颗粒/沸石和二氧化钛纳米颗粒/沸石分别显示出高达5次和6次的可重复使用性，且活性无显著损失。对比分析突出了二氧化钛纳米颗粒/沸石相对于氧化锌纳米颗粒/沸石的优越性能，这归因于较低的消耗量、较短的降解时间、更好的可重复使用性以及与较温和酸性条件的兼容性。总体而言，该研究展示了氧化锌纳米颗粒/沸石和二氧化钛纳米颗粒/沸石作为去除美托洛尔和阿替洛尔污染物的有效且可持续解决方案的潜力。
