Tuazon C U, Gill V, Gill F
Rev Infect Dis. 1986 Jan-Feb;8(1):54-60. doi: 10.1093/clinids/8.1.54.
Forty-eight patients with 51 episodes of infective endocarditis caused by streptococci were studied in a comparison of the efficacy of single antibiotic therapy versus that of combination therapy. There was no statistical difference in terms of clinical course, toxicity, and mortality between the group given a single drug and that given combination therapy. However, one patient experienced two relapses, in both instances after high-dose penicillin therapy. The species and antibiotic susceptibilities of the infecting organisms were determined. The majority of isolates were alpha-hemolytic, with Streptococcus sanguis recovered most commonly. Streptococcus bovis and group B beta-hemolytic streptococci were the next most frequent isolates.
对48例由链球菌引起51次感染性心内膜炎发作的患者进行了研究，比较单一抗生素治疗与联合治疗的疗效。接受单一药物治疗的组与接受联合治疗的组在临床病程、毒性和死亡率方面没有统计学差异。然而，有1例患者出现了两次复发，均发生在大剂量青霉素治疗之后。确定了感染病原体的种类和抗生素敏感性。大多数分离株为α溶血性，最常见的是血链球菌。牛链球菌和B组β溶血性链球菌是其次最常见的分离株。
