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调强放射治疗后腮腺内复发性鼻咽癌：一例报告

Intra-Parotid Recurrent Nasopharyngeal Carcinoma Following Intensity-Modulated Radiation Therapy: A Case Report.

作者信息

Bourial Abderrahim, Nourallah Laraqui Othmane, Abdillahi Mahamoud Chirwa, Elhani Hiba, Elmjabber Reyzane, Taali Loubna, Anajar Said, Essaadi Mustapha, Snoussi Khalid, Dahbi Zineb, Hajjij Amal

机构信息

Department of Oto-laryngology, Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.

Cheikh Khalifa International University Hospital, Mohammed VI University of Sciences and Health (UM6SS), Casablanca, Morocco.

出版信息

Clin Med Insights Case Rep. 2024 Nov 7;17:11795476241295723. doi: 10.1177/11795476241295723. eCollection 2024.

DOI:10.1177/11795476241295723
PMID:39525331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11544682/
Abstract

INTRODUCTION

Intra-parotid metastasis refers to the spread of cancerous cells from a primary tumor to the lymph nodes within the parotid gland. To our best knowledge, we report the first described case in the literature of a patient who received IMRT for nasopharyngeal carcinoma (UCNT) without sparing the parotid gland and still experienced a recurrence.

CASE PRESENTATION

A 57-year-old male patient of north African origin presented with a left parotid mass that had been evolving for 6 months. He was previously diagnosed with and treated for nasopharyngeal carcinoma 2 years prior to admission, with Intensity-Modulated Radiotherapy (IMRT) without sparing the parotid gland, as well as chemotherapy. Medical imaging was suggestive of recurrence of nasopharyngeal carcinoma and metastasis due to the patient's medical history. The patient benefited from a total parotidectomy; The histopathological analysis of the surgical specimen confirmed the presence of a poorly differentiated carcinoma (UCNT) with nodal metastasis.

CONCLUSION

Intensity-Modulated Radiation Therapy (IMRT) holds great promise as an alternative treatment option. However, it should be reserved for specific cases with minimal lymph node involvement, and always preceded by a thorough clinical and radiological examination.

摘要

引言

腮腺内转移是指癌细胞从原发肿瘤扩散至腮腺内的淋巴结。据我们所知，我们报告了文献中首例未对腮腺进行保护而接受调强放射治疗（IMRT）的鼻咽癌患者仍出现复发的病例。

病例介绍

一名57岁的北非男性患者出现左侧腮腺肿物，已持续6个月。他在入院前2年曾被诊断为鼻咽癌并接受了调强放射治疗（IMRT），未对腮腺进行保护，同时还接受了化疗。由于患者的病史，医学影像提示鼻咽癌复发及转移。患者接受了全腮腺切除术；手术标本的组织病理学分析证实存在低分化癌（鼻咽癌）伴淋巴结转移。

结论

调强放射治疗（IMRT）作为一种替代治疗选择具有很大的前景。然而，它应仅用于淋巴结受累最少的特定病例，并且始终要先进行全面的临床和放射学检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/d0ec9be96378/10.1177_11795476241295723-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/1ddb47dfd627/10.1177_11795476241295723-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/91ff2edcf607/10.1177_11795476241295723-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/d0ec9be96378/10.1177_11795476241295723-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/1ddb47dfd627/10.1177_11795476241295723-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/91ff2edcf607/10.1177_11795476241295723-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9037/11544682/d0ec9be96378/10.1177_11795476241295723-fig3.jpg

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本文引用的文献

1
"Reinforcement" by Tumor Microenvironment: The Seventh "R" of Radiobiology.肿瘤微环境的“强化作用”：放射生物学的第七个“R”
Int J Radiat Oncol Biol Phys. 2024 Jul 1;119(3):727-733. doi: 10.1016/j.ijrobp.2023.09.027. Epub 2023 Nov 29.
2
The role of cancer stromal fibroblasts in mediating the effects of tobacco-induced cancer cell growth.癌症基质成纤维细胞在介导烟草诱导的癌细胞生长效应中的作用。
Cancer Cell Int. 2021 Dec 25;21(1):707. doi: 10.1186/s12935-021-02414-9.
3
Randomized trial on acute toxicities of weekly vs three-weekly cisplatin-based chemoradiation in head and neck cancer.
随机试验比较头颈部癌症中每周与三周顺铂为基础的放化疗的急性毒性。
Cancer Rep (Hoboken). 2022 Jan;5(1):e1425. doi: 10.1002/cnr2.1425. Epub 2021 Jun 7.
4
Autophagy in fibroblasts induced by cigarette smoke extract promotes invasion in lung cancer cells.香烟烟雾提取物诱导的成纤维细胞自噬促进肺癌细胞侵袭。
Int J Cancer. 2020 Nov 1;147(9):2587-2596. doi: 10.1002/ijc.33127. Epub 2020 Jun 20.
5
The 6th R of Radiobiology: Reactivation of Anti-Tumor Immune Response.放射生物学的第六个R：抗肿瘤免疫反应的重新激活。
Cancers (Basel). 2019 Jun 20;11(6):860. doi: 10.3390/cancers11060860.
6
Mitochondrial toxicity of tobacco smoke and air pollution.烟草烟雾和空气污染的线粒体毒性。
Toxicology. 2017 Nov 1;391:18-33. doi: 10.1016/j.tox.2017.08.002. Epub 2017 Aug 22.
7
Metastasis of nasopharyngeal carcinoma to parotid lymph nodes: a retrospective study.鼻咽癌转移至腮腺淋巴结：一项回顾性研究。
World J Surg Oncol. 2015 Jan 26;13:1. doi: 10.1186/1477-7819-13-1.
8
Somatic alterations in mitochondrial DNA and mitochondrial dysfunction in gastric cancer progression.线粒体DNA的体细胞改变与胃癌进展中的线粒体功能障碍
World J Gastroenterol. 2014 Apr 14;20(14):3950-9. doi: 10.3748/wjg.v20.i14.3950.
9
Recurrence of nasopharyngeal carcinoma in the parotid region after definitive intensity-modulated radiotherapy.鼻咽癌在接受确定性调强放疗后腮腺区复发
J Oral Maxillofac Surg. 2013 Nov;71(11):1993-7. doi: 10.1016/j.joms.2013.04.002.
10
Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression.线粒体复合物 I 活性和 NAD+/NADH 平衡调节乳腺癌的进展。
J Clin Invest. 2013 Mar;123(3):1068-81. doi: 10.1172/JCI64264. Epub 2013 Feb 15.