Gu Ying-Ying, Zhao Xin-Ru, Zhang Nan, Yang Yuan, Yi Ying, Shao Qian-Hang, Liu Ming-Xuan, Zhang Xiao-Ling
College of Pharmacy, Nantong University, Nantong 226001, PR China.
Department of Gastroenterology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, PR China.
Ageing Res Rev. 2024 Dec;102:102577. doi: 10.1016/j.arr.2024.102577. Epub 2024 Nov 10.
Neurodegenerative diseases, as common diseases in the elderly, tend to become younger due to environmental changes, social development and other factors. They are mainly characterized by progressive loss or dysfunction of neurons in the central or peripheral nervous system, and common diseases include Parkinson's disease, Alzheimer's disease, Huntington's disease and so on. Mitochondria are important organelles for adenosine triphosphate (ATP) production in the brain. In recent years, a large amount of evidence has shown that mitochondrial dysfunction plays a direct role in neurodegenerative diseases, which is expected to provide new ideas for the treatment of related diseases. This review will summarize the main mechanisms of mitochondrial dysfunction in neurodegenerative diseases, as well as collating recent advances in the study of mitochondrial disorders and new therapies.
神经退行性疾病作为老年人的常见疾病，由于环境变化、社会发展等因素，有年轻化的趋势。它们主要特征是中枢或周围神经系统中神经元的渐进性丧失或功能障碍，常见疾病包括帕金森病、阿尔茨海默病、亨廷顿病等。线粒体是大脑中产生三磷酸腺苷（ATP）的重要细胞器。近年来，大量证据表明线粒体功能障碍在神经退行性疾病中起直接作用，有望为相关疾病的治疗提供新思路。本综述将总结神经退行性疾病中线粒体功能障碍的主要机制，以及整理线粒体疾病研究的最新进展和新疗法。
