首例人体研究：淋巴瘤患者的超极化1-13C-丙酮酸磁共振波谱与18F-FDG PET（超PET）同步成像
First-in-Human: Simultaneous Hyperpolarized 1- 13 C-Pyruvate Magnetic Resonance Spectroscopy and 18 F-FDG PET (hyperPET) Imaging of a Patient With Lymphoma.
作者信息
Loft Mathias, Clemmensen Andreas, Christensen Emil Nørgaard, Denholt Charlotte Lund, Johannesen Helle Hjorth, Gillings Nic, Carlsen Esben Andreas, Clausen Malene Martini, Hutchings Martin, Andersen Thomas Lund, Ardenkjær-Larsen Jan Henrik, Kjaer Andreas
机构信息
From the Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Department of Health Technology, Technical University of Denmark, Lyngby, Denmark.
出版信息
Clin Nucl Med. 2025 Feb 1;50(2):186-187. doi: 10.1097/RLU.0000000000005534. Epub 2024 Nov 12.
Hyperpolarized 1- 13 C-pyruvate magnetic resonance spectroscopy (MRS) and MRS imaging (MRSI) offer noninvasive and real-time direct assessment of the altered metabolism of cancer cells known as the Warburg effect-a key hallmark of cancer. When combined with simultaneously acquired 18 F-FDG PET in a PET/MR scanner, coined hyperPET by us, this dual-modality may unveil cancer-type specific glucose metabolic phenotypes with potential implications for patient prognostication, treatment-response assessment, and prediction. We here present the first human data of simultaneously acquired hyperpolarized MRS/MRSI and PET performed in a PET/MR scanner-and the first human hyperpolarized MRS/MRSI data from a patient with lymphoma.
超极化1-13C-丙酮酸磁共振波谱（MRS）和磁共振波谱成像（MRSI）能够对癌细胞代谢改变进行无创且实时的直接评估，这种代谢改变即瓦伯格效应——癌症的一个关键特征。当与PET/MR扫描仪中同时采集的18F-FDG PET相结合时（我们将其命名为hyperPET），这种双模态技术可能会揭示癌症类型特异性的葡萄糖代谢表型，对患者的预后、治疗反应评估及预测具有潜在意义。我们在此展示了在PET/MR扫描仪中同时采集超极化MRS/MRSI和PET的首批人体数据，以及来自一名淋巴瘤患者的首批人体超极化MRS/MRSI数据。
Zotero 插件