CD200-CD200R通路：术后认知功能障碍中微胶质细胞极化的调节因子
CD200-CD200R Pathway: A Regulator of Microglial Polarization in Postoperative Cognitive Dysfunction.
作者信息
Sun Jie, Lei Daoyun
机构信息
Department of Anesthesiology, Zhongda Hospital Southeast University (Jiangbei), Nanjing, Jiangsu, 210044, People's Republic of China.
Department of Anesthesiology, Zhongda Hospital Southeast University, Nanjing, Jiangsu, 210009, People's Republic of China.
出版信息
J Inflamm Res. 2024 Nov 7;17:8421-8427. doi: 10.2147/JIR.S489895. eCollection 2024.
Microglial polarization refers to the ability of microglia to exhibit different functional states under various conditions. As the resident immune cells of the brain, changes in the functional state of microglia play a crucial role in the progression of postoperative cognitive dysfunction. Recent studies have indicated that CD200-CD200R signaling is associated with microglial polarization. This review focuses on the latest advancements regarding whether CD200-CD200R signaling can regulate microglial polarization and thereby influence postoperative cognitive dysfunction.
小胶质细胞极化是指小胶质细胞在不同条件下表现出不同功能状态的能力。作为大脑中的常驻免疫细胞，小胶质细胞功能状态的变化在术后认知功能障碍的进展中起着关键作用。最近的研究表明，CD200-CD200R信号传导与小胶质细胞极化有关。本综述聚焦于CD200-CD200R信号传导是否能够调节小胶质细胞极化，进而影响术后认知功能障碍的最新进展。
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