Department of Oncology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Graduate School of Peking Union Medical College, Beijing, China.
Front Immunol. 2024 Oct 28;15:1478205. doi: 10.3389/fimmu.2024.1478205. eCollection 2024.
Ground-glass nodules (GGNs) are generally considered an early stage of lung cancer. The imaging characteristics and curative efficacy of multiple GGNs as metastases remain unclear. Microsatellite instability-high (MSI-H) is a biomarker for immunotherapy. The therapeutic effect and prognosis for patients with MSI-H and Epidermal Growth Factor Receptor (EGFR)-sensitive mutation stays uncertain. Here, we report a case of a lung adenocarcinoma patient presenting with ground-glass metastases, MSI-H, and EGFR-sensitive mutation and provide clinical data on the efficacy and prognosis. We describe the predictive significance of carcinoembryonic antigen (CEA) for disease progression when there is inconsistency between treatment effectiveness and CEA changes.
磨玻璃结节（GGN）一般被认为是肺癌的早期阶段。多个 GGN 作为转移灶的影像学特征和疗效仍不清楚。微卫星不稳定性高（MSI-H）是免疫治疗的生物标志物。MSI-H 和表皮生长因子受体（EGFR）敏感突变患者的治疗效果和预后仍不确定。在这里，我们报告了一例肺腺癌患者表现为磨玻璃转移、MSI-H 和 EGFR 敏感突变，并提供了关于疗效和预后的临床数据。我们描述了当治疗效果和 CEA 变化不一致时癌胚抗原（CEA）对疾病进展的预测意义。
