School of Clinical Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Department of Pediatrics, Southwest Medical University, Luzhou, China.
Front Immunol. 2024 Oct 28;15:1485628. doi: 10.3389/fimmu.2024.1485628. eCollection 2024.
Current research is focused on utilizing EVs as a biopsy tool to improve the diagnostic accuracy of HCC, reduce surgical risk, and explore their potential in modulating drug resistance and advancing immunotherapeutic strategies. Extracellular vesicles (EVs) have been increasingly recognized as important non-invasive biomarkers in hepatocellular carcinoma (HCC) due to the presence of a variety of biomolecules within them, such as proteins and RNAs, etc. EVs play a key role in the early detection, diagnosis, treatment, and prognostic monitoring of HCC. These vesicles influence the development of HCC and therapeutic response in a variety of ways, including influencing the tumor microenvironment, modulating drug resistance, and participating in immune regulatory mechanisms. In addition, specific molecules such as miRNAs and specific proteins in EVs are regarded as potential markers for monitoring treatment response and recurrence of HCC, which have certain research space and development prospects. In this paper, we summarize the aspects of EVs as HCC diagnostic and drug resistance markers, and also discuss the questions that may be faced in the development of EVs as markers.
目前的研究集中在利用 EVs 作为活检工具，以提高 HCC 的诊断准确性，降低手术风险，并探索它们在调节耐药性和推进免疫治疗策略方面的潜力。由于其中存在多种生物分子，如蛋白质和 RNA 等，细胞外囊泡 (EVs) 已越来越被认为是肝细胞癌 (HCC) 的重要非侵入性生物标志物。EVs 在 HCC 的早期检测、诊断、治疗和预后监测中发挥着关键作用。这些囊泡通过多种方式影响 HCC 的发展和治疗反应，包括影响肿瘤微环境、调节耐药性和参与免疫调节机制。此外，EV 中的特定分子（如 miRNAs 和特定蛋白）被认为是监测 HCC 治疗反应和复发的潜在标志物，具有一定的研究空间和发展前景。本文总结了 EVs 作为 HCC 诊断和耐药性标志物的各个方面，并讨论了将 EVs 作为标志物可能面临的问题。
