根据国际妇产科联盟（FIGO）2018年分期系统，宫颈癌保留生育功能治疗的生殖、产科和肿瘤学结局：一项系统综述。

Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review.

作者信息

Taliento Cristina, Scutiero Gennaro, Battello Ginevra, Sala Alessia, Pellecchia Giulia, Trozzi Rita, Arcieri Martina, Pavone Matteo, Bizzarri Nicolò, Greco Pantaleo, Driul Lorenza, Amant Frédéric, Fagotti Anna, Scambia Giovanni, Vizzielli Giuseppe, Restaino Stefano

机构信息

Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, Ferrara, Italy; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.

Department of Medical Sciences, Institute of Obstetrics and Gynecology, University of Ferrara, Ferrara, Italy.

出版信息

Eur J Surg Oncol. 2025 Jan;51(1):109359. doi: 10.1016/j.ejso.2024.109359. Epub 2024 Nov 7.

DOI:10.1016/j.ejso.2024.109359

PMID:39531915

Abstract

OBJECTIVE

We assessed reproductive, obstetrical, and oncological outcomes in patients who underwent fertility-sparing treatment by including studies that adhere to the FIGO 2018 staging system.

METHODS

Data on recurrence, mortality, pregnancy rate, live birth rate, and preterm delivery rate were collected.

RESULTS

In patients with stages IA1, IA2, and IB1, the recurrence rate was 4.7 % and the death rate was 0.6 %. For patients with stage IB2, the recurrence rate was 12.1 % and the death rate was 3.2 %. Pregnancy rates for conization/simple trachelectomy and radical trachelectomy were 61.7 % and 50 %, respectively. A higher live birth rate (84.4 % vs 58.6 %), and lower preterm birth rate (18.3 % vs 33.3 %) were observed in patients undergoing conization compared to radical trachelectomy.

CONCLUSION

We found a recurrence rate of 4.7 % in patients with stage less than or equal to IB1 and 12.1 % in those with stage IB2. A higher rate of preterm delivery was observed in patients who underwent radical trachelectomy.

摘要

目的

我们通过纳入遵循国际妇产科联盟（FIGO）2018分期系统的研究，评估了接受保留生育功能治疗的患者的生殖、产科和肿瘤学结局。

方法

收集复发、死亡率、妊娠率、活产率和早产率的数据。

结果

IA1期、IA2期和IB1期患者的复发率为4.7%，死亡率为0.6%。IB2期患者的复发率为12.1%，死亡率为3.2%。锥切术/单纯宫颈切除术和根治性宫颈切除术的妊娠率分别为61.7%和50%。与根治性宫颈切除术相比，接受锥切术的患者活产率更高（84.4%对58.6%），早产率更低（18.3%对33.3%）。