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老龄化人口中的 COPD 管理:病理生理学与综合护理的新视角。

Navigating COPD in Aging Populations: Insights Into Pathophysiology and Comprehensive Care.

机构信息

Division of Pulmonary and Critical Care Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

出版信息

Semin Respir Crit Care Med. 2024 Oct;45(5):560-573. doi: 10.1055/s-0044-1792112. Epub 2024 Nov 12.

Abstract

Chronic obstructive pulmonary disease (COPD) poses a significant and growing health burden among aging populations, marked by increasing prevalence and complex management challenges specific to elderly patients. This review explores the multifaceted interplay between COPD and aging, highlighting overlapping pathophysiological processes and comorbidities that complicate diagnosis and treatment. We examine age-specific management strategies, emphasizing the need for tailored approaches that account for the unique physical, cognitive, and health-related quality of life impacts on older adults. Additionally, we discuss preventive treatments and the critical roles of mental health, end-of-life care, and caregiver support in comprehensive disease management. The importance of integrative approaches to enhancing health care delivery is also underscored. Finally, we outline future directions, focusing on novel treatment pathways and the identification of biomarkers for early detection. Addressing these elements is essential for optimizing care in this vulnerable population and alleviating the significant societal and economic impacts of COPD among aging patients.

摘要

慢性阻塞性肺疾病(COPD)在老龄化人口中构成了重大且日益增长的健康负担,其特点是患病率不断上升,以及老年患者特有的复杂管理挑战。本综述探讨了 COPD 和衰老之间的多方面相互作用,强调了重叠的病理生理过程和合并症,这些过程使诊断和治疗变得复杂。我们研究了特定于年龄的管理策略,强调需要采用量身定制的方法,考虑到老年人独特的身体、认知和与健康相关的生活质量影响。此外,我们还讨论了预防治疗以及心理健康、临终关怀和护理人员支持在综合疾病管理中的关键作用。强调了综合方法在改善医疗保健提供方面的重要性。最后,我们概述了未来的方向,重点是新的治疗途径和早期检测生物标志物的识别。解决这些问题对于优化这一脆弱人群的护理以及减轻 COPD 在老年患者中的重大社会和经济影响至关重要。

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