Yasuda Y, Fujimoto T
Acta Anat (Basel). 1986;125(1):37-41. doi: 10.1159/000146134.
During the development of the mammalian secondary palate, the lateral palatine process (the palatal shelf) rises from the vertical plane beside the tongue to the horizontal plane above it. To determine the mode of elevation of the palatal shelf, we have cultured the whole ICR mouse fetus on day 14 (0-2 h) of gestation with a scratch as a marker at the distal edge of the anterior fourth of the vertical palatal shelf. After 6-18 h of culture, the survival ratio was 78.9%, and the palatal shelf rose horizontally above the tongue in 22.2% of the surviving fetuses. The scratch was found as a scar on the oral epithelium laterally to the medial edge of the elevated palatal shelf. These results indicate that the medial edge of the horizontal shelf was newly formed from the medial wall of the preceding vertical-stage shelf during elevation, and that the palatal shelf was elevated by a remodeling process in the anterior half of the shelf.
在哺乳动物次生腭的发育过程中，外侧腭突（腭架）从舌旁的垂直平面上升至其上方的水平平面。为了确定腭架的抬高方式，我们在妊娠第14天（0 - 2小时）培养了整个ICR小鼠胚胎，并在垂直腭架前四分之一的远端边缘处做了划痕作为标记。培养6 - 18小时后，存活率为78.9%，在存活的胚胎中，22.2%的腭架在舌上方水平抬高。在抬高的腭架内侧边缘外侧的口腔上皮上发现了划痕形成的瘢痕。这些结果表明，水平腭架的内侧边缘是在抬高过程中从前一个垂直阶段腭架的内侧壁新形成的，并且腭架是通过腭架前半部分的重塑过程抬高的。
