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甲状腺乳头状癌患者的Th17/Treg细胞平衡：一种新的潜在生物标志物和治疗靶点。

Th17/Treg cell balance in patients with papillary thyroid carcinoma: a new potential biomarker and therapeutic target.

作者信息

Huo Meng-Han, Adeerjiang Yilinuer, Abulitipu Ayiguzhali, Khan Umair, Li Xin-Xi, Zhang Lei, Tian Ye, Jiang Sheng, Xu Can-Can, Chao Xian-Zhen, Yang Ye-Fan, Zhang Jin-Xia, Du Guo-Li

机构信息

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, China.

Department of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

出版信息

Front Oncol. 2024 Oct 29;14:1325575. doi: 10.3389/fonc.2024.1325575. eCollection 2024.

DOI:10.3389/fonc.2024.1325575
PMID:39534095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11554530/
Abstract

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. The most effective treatment for PTC is surgical resection, and patients who undergo surgery have good survival outcomes, but some patients have distant metastasis or even multiorgan metastases at the time of initial diagnosis. Distant metastasis is associated with poorer prognosis and a higher mortality rate. Helper T lymphocyte 17 (Th17) cells and regulatory T lymphocytes (Tregs) play different roles in PTC, and the Th17/Treg balance is closely related to the progression of PTC. Th17 cells play anticancer roles, whereas Tregs play cancer-promoting roles. A Th17/Treg imbalance promotes tumor progression and accelerates invasive behaviors such as tumor metastasis. Th17/Treg homeostasis can be regulated by the TGF-β/IL-2 and IL-6 cytokine axes. Immune checkpoint inhibitors contribute to Treg/Th17 cell homeostasis. For PTC, monoclonal antibodies against CTLA-4, PD-1 and PD-L1 inhibit the activation of Tregs, reversing the Th17/Treg cell imbalance and providing a new option for the prevention and treatment of PTC. This article reviews the role of Tregs and Th17 cells in PTC and their potential targets, aiming to provide better treatment options for PTC.

摘要

甲状腺乳头状癌（PTC）是甲状腺癌最常见的亚型。PTC最有效的治疗方法是手术切除，接受手术的患者生存预后良好，但有些患者在初次诊断时就已发生远处转移甚至多器官转移。远处转移与较差的预后和较高的死亡率相关。辅助性T淋巴细胞17（Th17）细胞和调节性T淋巴细胞（Tregs）在PTC中发挥不同作用，且Th17/Treg平衡与PTC的进展密切相关。Th17细胞发挥抗癌作用，而Tregs发挥促癌作用。Th17/Treg失衡促进肿瘤进展并加速肿瘤转移等侵袭行为。Th17/Treg稳态可由TGF-β/IL-2和IL-6细胞因子轴调节。免疫检查点抑制剂有助于Treg/Th17细胞稳态。对于PTC，抗CTLA-4、PD-1和PD-L1单克隆抗体可抑制Tregs的激活，逆转Th17/Treg细胞失衡，为PTC的防治提供新选择。本文综述了Tregs和Th17细胞在PTC中的作用及其潜在靶点，旨在为PTC提供更好的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/e0fb150d9521/fonc-14-1325575-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/25d3ee2b4c38/fonc-14-1325575-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/3e492016b7c1/fonc-14-1325575-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/e0fb150d9521/fonc-14-1325575-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/25d3ee2b4c38/fonc-14-1325575-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/abda7ec684be/fonc-14-1325575-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/ae47da4040af/fonc-14-1325575-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/3e492016b7c1/fonc-14-1325575-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d963/11554530/e0fb150d9521/fonc-14-1325575-g005.jpg

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