Department of Geriatrics, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-Chemical Injury Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang Province, China.
World J Gastroenterol. 2024 Nov 7;30(41):4461-4480. doi: 10.3748/wjg.v30.i41.4461.
With the increasing of the global aging population, healthy aging and prevention of age-related diseases have become increasingly important. The liver, a vital organ involved in metabolism, detoxification, digestion, and immunity, holds a pivotal role in the aging process of organisms. Although extensive research on liver aging has been carried out, no bibliometric analysis has been conducted to evaluate the scientific progress in this area.
To analyze basic knowledge, development trends, and current research frontiers in the field bibliometric methods.
We conducted bibliometric analyses a range of analytical tools including Python, the bibliometrix package in R, CiteSpace, and VOSviewer. We retrieved publication data on liver aging research from the Web of Science Core Collection Database. A scientific knowledge map was constructed to display the contributions from different authors, journals, countries, institutions, as well as patterns of co-occurrence keywords and co-cited references. Additionally, gene regulation pathways associated with liver aging were analyzed the STRING database.
We identified 4288 articles on liver aging, authored by 24034 contributors from 4092 institutions across 85 countries. Notably, the years 1991 and 2020 presented significant bursts in publication output. The United States led in terms of publications ( = 1008, 25.1%), citations ( = 55205), and international collaborations (multiple country publications = 214). Keywords such as "lipid metabolism", "fatty liver disease", "inflammation", "liver fibrosis" and "target" were prominent, highlighting the current research hotspots. Notably, the top 64 genes, each of which appeared in at least 8 articles, were involved in pathways essential for cell survival and aging, including the phosphatidylinositol 3-kinase/protein kinase B, Forkhead box O and p53 signaling pathways.
This study highlights key areas of liver aging and offers a comprehensive overview of research trends, as well as insights into potential value for collaborative pursuits and clinical implementations.
随着全球人口老龄化的加剧，健康老龄化和预防与年龄相关的疾病变得越来越重要。肝脏作为参与代谢、解毒、消化和免疫的重要器官，在生物体衰老过程中起着关键作用。尽管对肝脏衰老进行了广泛的研究，但尚未进行文献计量分析来评估该领域的科学进展。
使用文献计量学方法分析肝脏衰老领域的基础知识、发展趋势和当前研究前沿。
我们使用 Python、R 中的 bibliometrix 包、CiteSpace 和 Vosviewer 等一系列分析工具进行了文献计量分析。我们从 Web of Science Core Collection 数据库中检索了关于肝脏衰老研究的出版物数据。构建了科学知识图谱，以显示不同作者、期刊、国家、机构的贡献，以及共现关键词和共被引参考文献的模式。此外，还通过 STRING 数据库分析了与肝脏衰老相关的基因调控途径。
我们确定了 4288 篇关于肝脏衰老的文章，这些文章的作者来自 85 个国家的 4092 个机构的 24034 位贡献者。值得注意的是，1991 年和 2020 年的出版物产出出现了显著的爆发。美国在出版物数量（ = 1008，25.1%）、引用次数（ = 55205）和国际合作（多国出版物 = 214）方面处于领先地位。突出的关键词包括“脂质代谢”、“脂肪肝疾病”、“炎症”、“肝纤维化”和“靶标”，突出了当前的研究热点。值得注意的是，出现至少 8 篇文章的前 64 个基因涉及细胞存活和衰老的关键途径，包括磷脂酰肌醇 3-激酶/蛋白激酶 B、叉头框 O 和 p53 信号通路。
本研究强调了肝脏衰老的关键领域，并全面概述了研究趋势，为合作追求和临床实施提供了潜在价值的见解。
