Yamaguchi I, Akimoto Y, Nakajima H, Kiyomoto A
Jpn J Pharmacol. 1979 Jun;29(3):375-83. doi: 10.1254/jjp.29.375.
Effect of diltiazem on insulin secretion was investigated in the perfused rat pancreas. Experiments were also carried out in anesthetized dogs and conscious rats with and without glucose loading. In the perfused rat pancreas, diltiazem reduced both glucose- and tolbutamide-induced insulin secretion and these effects of diltiazem were reversed with removal of the compound. Inhibition of the glucose-induced insulin secretion caused by diltiazem was counteracted by increasing the concentration of calcium ion. In experiments on intact animals, diltiazem at vasoactive doses produced no significant influence on the basal level of plasma insulin or glucose-induced insulin secretion. These data taken together with findings in previously reported work suggest that diltiazem reduces insulin secretion from pancreatic B-cells in vitro possibly by the calcium-antagonistic property, while the compound exhibits practically no inhibitory action on the insulin secretion in vivo.
在灌注大鼠胰腺中研究了地尔硫䓬对胰岛素分泌的影响。还在麻醉犬和清醒大鼠中进行了有无葡萄糖负荷的实验。在灌注大鼠胰腺中，地尔硫䓬降低了葡萄糖和甲苯磺丁脲诱导的胰岛素分泌，且去除该化合物后地尔硫䓬的这些作用会逆转。增加钙离子浓度可抵消地尔硫䓬对葡萄糖诱导的胰岛素分泌的抑制作用。在完整动物实验中，血管活性剂量的地尔硫䓬对血浆胰岛素基础水平或葡萄糖诱导的胰岛素分泌无显著影响。这些数据与先前报道的研究结果表明，地尔硫䓬在体外可能通过钙拮抗特性降低胰腺β细胞的胰岛素分泌，而该化合物在体内对胰岛素分泌几乎没有抑制作用。
