School of Rehabilitation, Capital Medical University, Beijing, China; Department of Neurological Rehabilitation, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing, China.
Department of Rehabilitation Medicine, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Clin Neurol Neurosurg. 2024 Dec;247:108631. doi: 10.1016/j.clineuro.2024.108631. Epub 2024 Nov 7.
The genetic relationship between daily physical activity (PA) levels and functional outcome after ischemic stroke remains unclear. This study aimed to investigate the genetic associations of PA on functional outcome after ischemic stroke using Mendelian randomization (MR).
We conducted two-sample MR analyses using genome-wide association studies (GWASs). This included data on light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) from the UK Biobank, and functional outcome after ischemic stroke from the Genetics of ischemic stroke Functional Outcome (GISCOME). The inverse-variance weighted (IVW) method served as our primary MR analysis approach, supplemented by several sensitivity analyses.
In univariable Mendelian randomization (UVMR) analysis, MVPA was significantly associated with a reduced risk of poor functional outcome (OR = 0.15, 95 % CI = 0.04-0.56, P < 0.01), whereas LPA had no genetic relationship (OR = 0.37, 95 % CI = 0.002-51.40, P = 0.69). In multivariate Mendelian randomization (MVMR) analysis adjusting for potentially confounding traits including hypertension, type 2 diabetes, and smoking, the overall patterns between MVPA and poststroke outcome remained (OR = 0.23, 95 % CI = 0.07-0.78, P = 0.02).
MVPA is a protective factor for functional outcome after ischemic stroke. This finding is important for the rehabilitation and functional outcome of stroke patients.
日常体力活动（PA）水平与缺血性卒中后功能结局之间的遗传关系尚不清楚。本研究旨在使用孟德尔随机化（MR）研究 PA 对缺血性卒中后功能结局的遗传相关性。
我们使用两样本 MR 分析，包括 UK Biobank 的轻度体力活动（LPA）和中高强度体力活动（MVPA）数据，以及 Genetics of ischemic stroke Functional Outcome （GISCOME）的缺血性卒中后功能结局数据。反方差加权（IVW）法作为我们的主要 MR 分析方法，辅以几种敏感性分析。
在单变量 Mendelian 随机化（UVMR）分析中，MVPA 与不良功能结局风险降低显著相关（OR=0.15，95%CI=0.04-0.56，P<0.01），而 LPA 与遗传无关联（OR=0.37，95%CI=0.002-51.40，P=0.69）。在多变量 Mendelian 随机化（MVMR）分析中，调整了高血压、2 型糖尿病和吸烟等潜在混杂因素后，MVPA 与卒中后结局之间的总体模式仍然存在（OR=0.23，95%CI=0.07-0.78，P=0.02）。
MVPA 是缺血性卒中后功能结局的保护因素。这一发现对于卒中患者的康复和功能结局具有重要意义。
