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一种迷走神经主导的四突触上行通路，用于处理胃痛。

A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing.

机构信息

Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou, China.

Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Nat Commun. 2024 Nov 13;15(1):9824. doi: 10.1038/s41467-024-54056-w.

DOI:10.1038/s41467-024-54056-w
PMID:39537596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11561356/
Abstract

Gastric pain has limited treatment options and the mechanisms within the central circuitry remain largely unclear. This study investigates the central circuitry in gastric pain induced by noxious gastric distension (GD) in mice. Here, we identified that the nucleus tractus solitarius (NTS) serves as the first-level center of gastric pain, primarily via the vagus nerve. The prelimbic cortex (PL) is engaged in the perception of gastric pain. The lateral parabrachial nucleus (LPB) and the paraventricular thalamic nucleus (PVT) are crucial regions for synaptic transmission from the NTS to the PL. The glutamatergic tetra-synaptic NTS-LPB-PVT-PL circuitry is necessary and sufficient for the processing of gastric pain. Overall, our finding reveals a glutamatergic tetra-synaptic NTS-LPB-PVT-PL circuitry that transmits gastric nociceptive signaling by the vagus nerve in mice. It provides an insight into the gastric pain ascending pathway and offers potential therapeutic targets for relieving visceral pain.

摘要

胃疼痛的治疗选择有限，其中枢回路的机制在很大程度上仍不清楚。本研究在小鼠有害性胃扩张（GD）诱导的胃疼痛中调查了中枢回路。在这里，我们确定孤束核（NTS）作为胃疼痛的第一级中枢，主要通过迷走神经。额前皮质（PL）参与胃疼痛的感知。外侧臂旁核（LPB）和室旁丘脑核（PVT）是 NTS 到 PL 的突触传递的关键区域。谷氨酸能四突触 NTS-LPB-PVT-PL 回路对于胃疼痛的处理是必要且充分的。总的来说，我们的发现揭示了一个谷氨酸能四突触 NTS-LPB-PVT-PL 回路，通过迷走神经在小鼠中传递胃伤害性信号。它为胃疼痛上行通路提供了深入了解，并为缓解内脏疼痛提供了潜在的治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/a43e0197715b/41467_2024_54056_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/ee60ac1ed2fb/41467_2024_54056_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/b561a06379f7/41467_2024_54056_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/e9aaa70ee7dd/41467_2024_54056_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/28b6955c8ca3/41467_2024_54056_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/49a846d2850a/41467_2024_54056_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/b90d4e33edbd/41467_2024_54056_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/8795ed566382/41467_2024_54056_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/a43e0197715b/41467_2024_54056_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/ee60ac1ed2fb/41467_2024_54056_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/b561a06379f7/41467_2024_54056_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/e9aaa70ee7dd/41467_2024_54056_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/28b6955c8ca3/41467_2024_54056_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/49a846d2850a/41467_2024_54056_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/b90d4e33edbd/41467_2024_54056_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/8795ed566382/41467_2024_54056_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b0f/11561356/a43e0197715b/41467_2024_54056_Fig8_HTML.jpg

相似文献

[1]
A vagus nerve dominant tetra-synaptic ascending pathway for gastric pain processing.

Nat Commun. 2024-11-13

[2]
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[3]
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[4]
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[5]
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[6]
Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat.

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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
Transcutaneous Auricular Vagus Nerve Stimulation for Postpartum Contraction Pain During Elective Cesarean Delivery: A Randomized Clinical Trial.

JAMA Netw Open. 2025-8-1

[2]
Endothelin A receptor in nociceptors is essential for persistent mechanical pain in a chronic pancreatitis of mouse model.

World J Gastroenterol. 2025-6-21

[3]
Cutaneous Allodynia of the Withers in Cattle: An Experimental In Vivo Neuroanatomical Preliminary Investigation of the Dichotomizing Sensory Neurons Projecting into the Reticulum and Skin of the Withers-A Case Study on Two Calves.

Animals (Basel). 2025-6-6

[4]
From sensation to regulation: the diverse functions of peripheral sensory nervous system.

Front Immunol. 2025-5-16

[5]
Upregulation of NR2A in Glutamatergic VTA Neurons Contributes to Chronic Visceral Pain in Male Mice.

Neurosci Bull. 2025-4-28

[6]
Upregulation of NR2B Subunits of NMDA Receptors in the Lateral Parabrachial Nucleus Contributes to Chronic Pancreatitis Pain.

CNS Neurosci Ther. 2025-3

本文引用的文献

[1]
Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone.

Cell. 2024-6-20

[2]
Neural circuits regulating visceral pain.

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Natl Sci Rev. 2023-9-27

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Elife. 2023-12-7

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Paraventricular thalamus-insular cortex circuit mediates colorectal visceral pain induced by neonatal colonic inflammation in mice.

CNS Neurosci Ther. 2024-4

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Nature. 2023-12

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