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绿色合成的氧化锌纳米颗粒：对三维乳腺癌模型的抗癌功效

Green synthesized -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model.

作者信息

Alhaddad Ruqaya, Abualsoud Bassam M, Al-Deeb Ibrahim, Nsairat Hamdi

机构信息

Pharmacological & Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman, 19328, Jordan.

Department of Clinical Pharmacy, Faculty of Pharmacy, Zarqa University, Zarqa, 13110, Jordan.

出版信息

Future Sci OA. 2024 Dec 31;10(1):2419806. doi: 10.1080/20565623.2024.2419806. Epub 2024 Nov 14.

DOI:10.1080/20565623.2024.2419806
PMID:39539163
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11572278/
Abstract

ZnO NPs were prepared via green synthesis utilizing . Physical characterization and biological activity were performed against 2D, and 3D spheroids MCF-7 cell lines. The NPs exhibited 188.9, 175.7 and 171.2 nm size with charge of -8.2, -11.7 and -9.7 mV for the 2%, 3% and 4% formulations. XRD confirmed a wurtzite hexagonal phase. FTIR spectra showed Zn-O stretching vibrations. The 2%, 3% and 4% formulations presented IC values of 14.7, 26.2 and 47 μg/ml, respectively, with complete destruction of MCF-7 spheroids. Elevated levels suggested an inflammatory-mediated mechanism of action. 2% -derived ZnO NPs showed antitumor potential against deserving further mechanistic and explorations.

摘要

通过绿色合成法制备了氧化锌纳米颗粒（ZnO NPs）。对二维和三维球体MCF - 7细胞系进行了物理表征和生物活性研究。对于2%、3%和4%的配方，纳米颗粒的尺寸分别为188.9、175.7和171.2纳米，电荷分别为 - 8.2、 - 11.7和 - 9.7毫伏。X射线衍射（XRD）证实为纤锌矿六方相。傅里叶变换红外光谱（FTIR）显示了Zn - O伸缩振动。2%、3%和4%的配方的半数抑制浓度（IC）值分别为14.7、26.2和47微克/毫升，MCF - 7球体被完全破坏。水平升高表明存在炎症介导的作用机制。2%的氧化锌纳米颗粒显示出抗肿瘤潜力，值得进一步进行机制和探索研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/4ec4a38b76e7/IFSO_A_2419806_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/5e8c4fa21b03/IFSO_A_2419806_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/5a1fa86af4e9/IFSO_A_2419806_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/5ecf9227896e/IFSO_A_2419806_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/e1de80f403aa/IFSO_A_2419806_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/4ec4a38b76e7/IFSO_A_2419806_F0005_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/5e8c4fa21b03/IFSO_A_2419806_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/5a1fa86af4e9/IFSO_A_2419806_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/5ecf9227896e/IFSO_A_2419806_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/e1de80f403aa/IFSO_A_2419806_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8167/11572278/4ec4a38b76e7/IFSO_A_2419806_F0005_B.jpg

相似文献

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Green synthesized -ZnO nanoparticles: anticancer efficacy against 3D breast cancer model.

Future Sci OA. 2024-12-31

[2]
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[3]
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[6]
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[7]
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[8]
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[9]
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[10]
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本文引用的文献

[1]
Therapeutic efficiency of Tamoxifen/Orlistat nanocrystals against solid ehrlich carcinoma via targeting TXNIP/HIF1-α/MMP-9/P27 and BAX/Bcl2/P53 signaling pathways.

Biomed Pharmacother. 2024-11

[2]
Oleuropein impact on colorectal cancer.

Future Sci OA. 2024-5-23

[3]
Encapsulation of gingerol into nanoliposomes: Evaluation of in vitro anti-inflammatory and anti-cancer activity.

Biomed Chromatogr. 2024-8

[4]
Formulation optimization of lyophilized aptamer-gold nanoparticles: Maintained colloidal stability and cellular uptake.

Heliyon. 2024-5-8

[5]
Meta-analysis of nano-phytosomes: unleashing the potential of plant-derived compounds for advancing cancer therapy.

Nat Prod Res. 2024-4-26

[6]
evaluation of mebendazole and Ran GTPase inhibition in breast cancer model system.

Nanomedicine (Lond). 2024

[7]
Doxorubicin conjugates: a practical approach for its cardiotoxicity alleviation.

Expert Opin Drug Deliv. 2024-3

[8]
Preparation, characterization and evaluation of 5-fluorouracil loaded into chitosan-acacia gum nanoparticles.

Ther Deliv. 2024-3-12

[9]
Dual-loaded liposomal carriers to combat chemotherapeutic resistance in breast cancer.

Expert Opin Drug Deliv. 2024-2

[10]
The impact of the BCR-ABL oncogene in the pathology and treatment of chronic myeloid leukemia.

Pathol Res Pract. 2024-2

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