Yang Jingjie
Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang, 443002, China.
College of Basic Medical Science, China Three Gorges University, Yichang, 443002, China.
Heliyon. 2024 Oct 26;10(21):e39857. doi: 10.1016/j.heliyon.2024.e39857. eCollection 2024 Nov 15.
Forkhead box P4 antisense RNA 1 (FOXP4-AS1) is a long non-coding RNA (lncRNA) situated on the human chromosome 6p21.1 locus. Previous research has demonstrated that FOXP4-AS1 is dysregulated in various cancers and exhibits a dual purpose as a tumor suppressor or oncogene in specific types of cancer. The levels of FOXP4-AS1 are significantly correlated with clinical features of cancer as well as prognosis. Additionally, FOXP4-AS1 is stimulated by transcription factors ATF3, YY1, PAX5, and SP4. The molecular mechanisms of FOXP4-AS1 in cancer are quite complex. It competitively sponges multiple miRNAs, bidirectionally regulates the levels of host gene FOXP4, activates the PI3K/AKT, Wnt/β-catenin, and ERK/MAPK signaling pathways, and recruits chromatin-modifying enzymes or interacts with other proteins to regulate malignant phenotypes of tumors, including proliferation, invasion, epithelial-mesenchymal transition (EMT), and angiogenesis. In this review, we provide an overview of the latest developments in FOXP4-AS1 oncology research, outlines its molecular regulatory networks in cancer, and discusses its prospective relevance as a cancer therapeutic target as well as a biomarker for prognosis and diagnosis.
叉头框P4反义RNA 1（FOXP4-AS1）是一种长链非编码RNA（lncRNA），位于人类染色体6p21.1位点。先前的研究表明，FOXP4-AS1在多种癌症中表达失调，并且在特定类型的癌症中具有作为肿瘤抑制因子或癌基因的双重作用。FOXP4-AS1的水平与癌症的临床特征以及预后显著相关。此外，FOXP4-AS1受转录因子ATF3、YY1、PAX5和SP4的刺激。FOXP4-AS1在癌症中的分子机制相当复杂。它竞争性地吸附多种微小RNA（miRNA），双向调节宿主基因FOXP4的水平，激活PI3K/AKT、Wnt/β-连环蛋白和ERK/MAPK信号通路，并招募染色质修饰酶或与其他蛋白质相互作用以调节肿瘤的恶性表型，包括增殖、侵袭、上皮-间质转化（EMT）和血管生成。在本综述中，我们概述了FOXP4-AS1肿瘤学研究的最新进展，勾勒了其在癌症中的分子调控网络，并讨论了其作为癌症治疗靶点以及预后和诊断生物标志物的潜在相关性。
