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对裸盖菇素在心理健康方面潜力的叙述性探索。

A narrative exploration of psilocybin's potential in mental health.

作者信息

Min Huitae, Park Soon Young, Park Jisu, Na Seongsu, Lee Hoe-Suk, Kim Taejung, Ham Jungyeob, Park Young-Tae

机构信息

Natural Product Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Republic of Korea.

R&D Center, NeoCannBio Co., Ltd., Seoul, Republic of Korea.

出版信息

Front Psychiatry. 2024 Oct 30;15:1429373. doi: 10.3389/fpsyt.2024.1429373. eCollection 2024.

Abstract

Psilocybin, a psychoactive substance, has recently garnered attention for its high therapeutic potential in psychiatry. In this study, we investigated the multifaceted aspects of psilocybin, highlighting its chemical properties, mechanisms of action, and burgeoning role in psychiatric treatment. Furthermore, we examined the clinical applications and potential therapeutic benefits of psilocybin in the treatment of various mental health disorders, supported by accumulating clinical evidence. This review aims to deepen our understanding of the clinical impact of psilocybin, elucidate its therapeutic value, and propose directions for future research, thereby paving the way for its integration into mainstream psychiatric treatments. Psilocybin has been shown to be safe in clinical trials with manageable side effects. However, additional safety measures are required after this discussion, including dosing protocols, patient monitoring, and distress management strategies.

摘要

裸盖菇素是一种精神活性物质,最近因其在精神病学领域的高治疗潜力而备受关注。在本研究中,我们调查了裸盖菇素的多方面特性,重点介绍了其化学性质、作用机制以及在精神科治疗中日益凸显的作用。此外,在越来越多临床证据的支持下,我们研究了裸盖菇素在治疗各种心理健康障碍方面的临床应用和潜在治疗益处。本综述旨在加深我们对裸盖菇素临床影响的理解,阐明其治疗价值,并为未来研究提出方向,从而为将其纳入主流精神科治疗铺平道路。在临床试验中,裸盖菇素已被证明是安全的,副作用可控。然而,在本次讨论之后,还需要额外的安全措施,包括给药方案、患者监测和痛苦管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eed3/11557947/e3ddaac18fbe/fpsyt-15-1429373-g001.jpg

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