Tian Mengxiang, Li Fengyuan, Pei Haiping, Liu Xiaoling, Nie Hongyun
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China.
National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Front Med (Lausanne). 2024 Oct 30;11:1436091. doi: 10.3389/fmed.2024.1436091. eCollection 2024.
The innate immune system plays a vital role in the inflammatory process, serving as a crucial mechanism for the body to respond to infection, cellular stress, and tissue damage. The cGAS-STING signaling pathway is pivotal in the onset and progression of various autoimmune diseases and chronic inflammation. By recognizing cytoplasmic DNA, this pathway initiates and regulates inflammation and antiviral responses within the innate immune system. Consequently, the regulation of the cGAS-STING pathway has become a prominent area of interest in the treatment of many diseases. Chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis, are characterized by persistent or recurrent lung inflammation and tissue damage, leading to diminished respiratory function. This paper explores the mechanism of action of the cGAS-STING signaling pathway in these diseases, examines the development of STING inhibitors and nanomaterial applications, and discusses the potential clinical application prospects of targeting the cGAS-STING pathway in chronic inflammatory lung diseases.
先天性免疫系统在炎症过程中发挥着至关重要的作用，是机体对感染、细胞应激和组织损伤作出反应的关键机制。cGAS-STING信号通路在各种自身免疫性疾病和慢性炎症的发生和发展中起着关键作用。通过识别细胞质DNA，该通路启动并调节先天性免疫系统内的炎症和抗病毒反应。因此，cGAS-STING通路的调节已成为许多疾病治疗中一个备受关注的领域。慢性炎症性肺病，如慢性阻塞性肺疾病（COPD）、哮喘和肺纤维化，其特征是持续或反复的肺部炎症和组织损伤，导致呼吸功能下降。本文探讨了cGAS-STING信号通路在这些疾病中的作用机制，研究了STING抑制剂的开发和纳米材料的应用，并讨论了靶向cGAS-STING通路在慢性炎症性肺病中的潜在临床应用前景。
