Zhu Lili, Jiang Xiaohong
Chengdu University of Technology Logistics Service Group, Chengdu, China.
Department of Internal Medicine, the Hospital of Chengdu University of Technology, Chengdu, China.
Front Med (Lausanne). 2024 Oct 30;11:1439626. doi: 10.3389/fmed.2024.1439626. eCollection 2024.
The characteristics of blood lipid and metabolic indicators were analyzed in patients with subclinical hypothyroidism (SCH), and the effect of type 2 diabetes mellitus (T2DM) on SCH patients was determined.
The physical examination data of 2,119 residents in a university community were retrospectively divided into 2 groups (SCH and non-SCH groups). Furthermore, the SCH group was divided into SCH-T2DM and SCH-non-T2DM subgroups, and the data between the groups were analyzed.
The SCH group had significantly higher levels of triglycerides ( = 0.044), total cholesterol ( = 0.001), low-density lipoprotein cholesterol ( = 0.019), very low-density lipoprotein cholesterol ( = 0.044), 2-h plasma glucose ( = 0.023), and globulin ( = 0.000) compared to the non-SCH group. The SCH-T2DM group was older ( < 0.001), had a greater BMI ( = 0.028), a more rapid heart rate ( = 0.025), and a greater waist circumference ( < 0.001) than the SCH-non-T2DM group based on the subgroup analysis. The SCH-T2DM group had significantly higher dyslipidemia and dysglycemia levels than the SCH-non-T2DM group.
Patients with SCH with or without T2DM may have dyslipidemia and dysglycemia and should be evaluated accordingly.
分析亚临床甲状腺功能减退症（SCH）患者的血脂及代谢指标特征，并确定2型糖尿病（T2DM）对SCH患者的影响。
回顾性分析某大学社区2119名居民的体检数据，将其分为2组（SCH组和非SCH组）。此外，将SCH组再分为SCH-T2DM和SCH-非T2DM亚组，并分析组间数据。
与非SCH组相比，SCH组的甘油三酯（=0.044）、总胆固醇（=0.001）、低密度脂蛋白胆固醇（=0.019）、极低密度脂蛋白胆固醇（=0.044）、2小时血糖（=0.023）和球蛋白（=0.000）水平显著更高。亚组分析显示，SCH-T2DM组比SCH-非T2DM组年龄更大（<0.001）、体重指数更高（=0.028）、心率更快（=0.025）、腰围更大（<0.001）。SCH-T2DM组的血脂异常和血糖异常水平显著高于SCH-非T2DM组。
伴有或不伴有T2DM的SCH患者可能存在血脂异常和血糖异常，应据此进行评估。
