Li Jiani, Bao Xiaorui, Guo Shujia, Huang Yuhan, Huang Caihong, Hu Jiaoyue, Liu Zuguo
Xiamen University Affiliated Xiamen Eye Center, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361005, China.
State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, China.
Ocul Surf. 2024 Oct;34:535-544. doi: 10.1016/j.jtos.2024.11.004. Epub 2024 Nov 13.
Dry eye disease (DED) is increasingly prevalent, with inflammation playing a crucial role in its pathogenesis. Severe cases of DED result in significant ocular discomfort and visual impairment due to damage and loss of ocular surface epithelial cells. The precise mechanisms underlying the loss of these epithelial cells remain a subject of ongoing research and debate. Programmed cell death (PCD) mechanisms, including pyroptosis, apoptosis, and necroptosis, are known to be critical in maintaining ocular surface homeostasis and responding to stressors in DED. The concept of PANoptosis, which integrates elements of various PCD pathways, has been implicated in the development of numerous systemic diseases, including infections, cancer, neurodegenerative, and inflammatory conditions. It also provides novel insights into the inflammatory processes underlying DED. This review highlights the crosstalk of PCD pathways in DED, particularly the significance of PANoptosis in ocular inflammation and its potential as a therapeutic target for more effective interventions.
干眼症（DED）日益普遍，炎症在其发病机制中起着关键作用。严重的干眼症病例会因眼表上皮细胞的损伤和丧失而导致明显的眼部不适和视力损害。这些上皮细胞丧失的精确机制仍是一个正在研究和争论的主题。已知程序性细胞死亡（PCD）机制，包括细胞焦亡、凋亡和坏死性凋亡，在维持眼表稳态以及应对干眼症中的应激源方面至关重要。泛凋亡概念整合了各种PCD途径的要素，已被认为与包括感染、癌症、神经退行性疾病和炎症性疾病在内的多种全身性疾病的发展有关。它还为干眼症潜在的炎症过程提供了新的见解。本综述强调了干眼症中PCD途径的相互作用，特别是泛凋亡在眼部炎症中的重要性及其作为更有效干预治疗靶点的潜力。
