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[产科中的细胞回收——背景与实际应用]

[Cell salvage in obstetrics-Background and practical implementation].

作者信息

Kotlyar Mischa J, Neef Vanessa, Rumpf Florian, Meybohm Patrick, Zacharowski Kai, Kranke Peter

机构信息

Klinik und Poliklinik für Anästhesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Universitätsklinikum Würzburg, Oberdürrbacher Str. 6, 97080, Würzburg, Deutschland.

Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Goethe-Universität Frankfurt, Universitätsklinikum, Frankfurt, Deutschland.

出版信息

Anaesthesiologie. 2024 Dec;73(12):843-851. doi: 10.1007/s00101-024-01479-1.

Abstract

Postpartum hemorrhage (PPH) remains a leading cause of maternal mortality worldwide, with an increasing incidence in western countries over the past decades. During this period the numbers of PPH-related allogeneic red blood cell (RBC) transfusions have also significantly increased. Given the increasing scarcity and risks of allogeneic RBC transfusions, which are also associated with adverse maternal outcomes, optimized blood management strategies are urgently needed in obstetrics. In recent years, patient blood management (PBM) has been increasingly integrated into medical care, resulting in a significant improvement in patient outcomes. Cell salvage (CS) is one of the PBM blood-sparing techniques that enables the collection, processing and retransfusion of the patient's own blood during major bleeding events. Although recent evidence indicates that CS can significantly reduce the demand for allogeneic RBC transfusions and improve patient outcomes, the utilization in obstetrics in German hospitals remains low, with a usage rate of only 0.07% of births with peripartum hemorrhage. It must be assumed that concerns about patient-related complications, such as amniotic fluid embolism and maternal alloimmunization contribute to this hesitancy, alongside a lack of familiarity with the technique. This article provides an overview of the current evidence on the use and safety of CS in obstetrics. To facilitate a practical implementation, fundamental considerations and organizational precautions were prepared based on the experiences of the University Hospitals in Würzburg and Frankfurt and presented in the form of graphics and checklists for the perioperative use of CS during cesarean sections.

摘要

产后出血(PPH)仍然是全球孕产妇死亡的主要原因,在过去几十年中,西方国家的发病率呈上升趋势。在此期间,与PPH相关的异体红细胞(RBC)输血数量也显著增加。鉴于异体RBC输血日益稀缺且存在风险,同时还与不良的孕产妇结局相关,产科迫切需要优化的血液管理策略。近年来,患者血液管理(PBM)已越来越多地融入医疗护理中,从而显著改善了患者的结局。细胞回收(CS)是PBM的血液保护技术之一,可在大出血事件期间收集、处理和回输患者自身的血液。尽管最近的证据表明CS可以显著减少异体RBC输血的需求并改善患者结局,但德国医院产科对其利用率仍然很低,在围产期出血的分娩中使用率仅为0.07%。必须假定,除了对该技术缺乏了解之外,对患者相关并发症(如羊水栓塞和母体同种免疫)的担忧也导致了这种犹豫态度。本文概述了目前关于CS在产科应用和安全性的证据。为便于实际实施,根据维尔茨堡和法兰克福大学医院的经验,制定了基本考虑因素和组织预防措施,并以剖宫产术中CS围手术期使用的图表和检查表形式呈现。

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