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产科中细胞回收利用的当前概念。

Current concepts in the use of cell salvage in obstetrics.

作者信息

Neef Vanessa, Meybohm Patrick, Zacharowski Kai, Kranke Peter

机构信息

Goethe University Frankfurt, University Hospital, Department of Anesthesiology, Intensive Care Medicine and Pain Therapy.

University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany.

出版信息

Curr Opin Anaesthesiol. 2024 Jun 1;37(3):213-218. doi: 10.1097/ACO.0000000000001337. Epub 2024 Mar 12.

Abstract

PURPOSE OF REVIEW

The worldwide leading cause of maternal death is severe maternal hemorrhage. Maternal hemorrhage can be profound leading to an entire loss of blood volume. In the past two decades, Patient Blood Management has evolved to improve patient's care and safety. In surgeries with increased blood loss exceeding 500 ml, the use of cell salvage is strongly recommended in order to preserve the patient's own blood volume and to minimize the need for allogeneic red blood cell (RBC) transfusion. In this review, recent evidence and controversies of the use of cell salvage in obstetrics are discussed.

RECENT FINDINGS

Numerous medical societies as well as national and international guidelines recommend the use of cell salvage during maternal hemorrhage.

SUMMARY

Intraoperative cell salvage is a strategy to maintain the patient's own blood volume and decrease the need for allogeneic RBC transfusion. Historically, cell salvage has been avoided in the obstetric population due to concerns of iatrogenic amniotic fluid embolism (AFE) or induction of maternal alloimmunization. However, no definite case of AFE has been reported so far. Cell salvage is strongly recommended and cost-effective in patients with predictably high rates of blood loss and RBC transfusion, such as women with placenta accreta spectrum disorder. However, in order to ensure sufficient practical experience in a multiprofessional obstetric setting, liberal use of cell salvage appears advisable.

摘要

综述目的

全球范围内孕产妇死亡的主要原因是严重的孕产妇出血。孕产妇出血可能非常严重,导致血容量完全丧失。在过去二十年中,患者血液管理不断发展,以改善患者护理和安全。在失血超过500毫升的手术中,强烈建议使用血液回收,以保存患者自身的血容量,并尽量减少异体红细胞(RBC)输血的需求。在本综述中,讨论了血液回收在产科应用中的最新证据和争议。

最新发现

众多医学协会以及国家和国际指南都推荐在孕产妇出血时使用血液回收。

总结

术中血液回收是一种维持患者自身血容量并减少异体RBC输血需求的策略。从历史上看,由于担心医源性羊水栓塞(AFE)或诱发母体同种免疫,产科人群一直避免使用血液回收。然而,迄今为止尚未报告明确的AFE病例。对于预计失血率和RBC输血率较高的患者,如患有胎盘植入谱系障碍的女性,强烈建议并具有成本效益地使用血液回收。然而,为了确保在多专业产科环境中有足够的实践经验,似乎建议广泛使用血液回收。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b6f/11062610/9c73ccd20e3a/coana-37-213-g001.jpg

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