Liao Zhifeng, Ma Jianxun, Bu Xi, Zhang Yanjun, Wang Shiliang, Hou Yuxin, Clément Julien, Hu Xueqing, Bo Hongliang, Zeng Ang, Yu Nanze, Luo Sheng-Kang, Li Bi
Department of Plastic and Reconstructive Surgery, Guangdong Province, Guangdong Second Provincial General Hospital, 466 Middle Xin Gang Road, Guangzhou City, People's Republic of China.
Department of Plastic Surgery, Peking University Third Hospital, #49, North Garden Road, Haidian District, Beijing, People's Republic of China.
Aesthetic Plast Surg. 2025 Feb;49(4):1046-1053. doi: 10.1007/s00266-024-04494-0. Epub 2024 Nov 14.
The chin significantly influences facial aesthetics, contributing to the overall balance and harmony of the face. This study aimed to assess the effectiveness of the hyaluronic acid filler Hyamax® Volumizer for chin augmentation and correction of chin retrusion compared to a no-treatment control.
Participants aged 18-55 years with mild to moderate chin retrusion were randomized in a 3:1 ratio to receive either the treatment group (n = 150) or control group (n = 50). Evaluations included blinded assessments using the validated Galderma Chin Retrusion Scale, Global Aesthetic Improvement Scale for aesthetic enhancement, and safety follow-up.
The Galderma Chin Retrusion Scale responder rate (≥1 grade improvement) was significantly higher for the treatment group (70%) compared to the control group (0%) at 6 months (p < 0.0001), and remained higher at 12 months (54.67% vs. 0%; p < 0.0001). Aesthetic improvement rates were consistently high as reported by both blinded evaluating investigator (≥89.33%) and subjects (≥91.33%). Treatment-related adverse events were mild to moderate.
Hyamax® Volumizer treatment is safe and effective when injected in the chin to treat chin retrusion, with results lasting through 1 year.
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下巴对面部美学有显著影响，有助于面部整体的平衡与和谐。本研究旨在评估透明质酸填充剂Hyamax® Volumizer与不治疗对照组相比，在隆下巴和矫正下巴后缩方面的有效性。
将年龄在18 - 55岁、有轻度至中度下巴后缩的参与者按3:1的比例随机分组，治疗组（n = 150）或对照组（n = 50）。评估包括使用经过验证的高德美下巴后缩量表进行盲法评估、用于美学改善的全球美学改善量表以及安全性随访。
在6个月时，治疗组的高德美下巴后缩量表反应率（改善≥1级）显著高于对照组（70% vs. 0%；p < 0.0001），在12个月时仍保持较高水平（54.67% vs. 0%；p < 0.0001）。盲法评估的研究者（≥89.33%）和受试者（≥91.33%）报告的美学改善率一直很高。与治疗相关的不良事件为轻度至中度。
Hyamax® Volumizer注射到下巴治疗下巴后缩时安全有效，效果可持续1年。
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