Singh Deepika, Shukla Gaurav
Faculty of Health Sciences, Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, India.
Inflammopharmacology. 2025 Feb;33(2):505-525. doi: 10.1007/s10787-024-01596-8. Epub 2024 Nov 14.
Cancer is the predominant and major cause of fatality worldwide, based on the different types of cancer. There is a limitation in the current treatment. So we need better therapeutic agents that counteract the progression and development of malignant tumours. Plant-derived products are closely related and useful for human health. Luteolin is a polyphenolic flavonoid bioactive molecule that is present in various herbs, vegetables, fruits, and flowers and exhibits chemoprotective and pharmacological activity against different malignancies. To offer innovative approaches for the management of various cancers, we present a comprehensive analysis of the latest discoveries on luteolin. The aim is to inspire novel concepts for the development of advanced pharmaceuticals targeting cancer and search specifically targeted reviews and research articles published from January 1999 to January 2024 that investigated the application of luteolin in various cancer management. A thorough literature search utilizing the keywords "luteolin" "Signalling Pathway" "cancer" and nanoparticles was performed in the databases of Google Scholar, Web of Science, SCOPUS, UGC care list and PubMed. Through the compilation of existing research, we have discovered that luteolin possesses several therapeutic actions against various cancer via a signaling pathway involving the of NF-κB regulation, AMPK/mTOR, toll-like receptor, Nrf-2, PI3K/Akt MAPK and Wnt/β-catenin and their underlying mechanism of action has been well understood. This review intended to completely integrate crucial information on natural sources, biosynthesis, pharmacokinetics, signaling pathways, chemoprotective and therapeutic properties against various cancers, and nanoformulation of luteolin.
基于不同类型的癌症，癌症是全球主要的致死原因。当前的治疗存在局限性。因此，我们需要更好的治疗药物来对抗恶性肿瘤的进展和发展。植物衍生产品与人类健康密切相关且十分有用。木犀草素是一种多酚类黄酮生物活性分子，存在于各种草药、蔬菜、水果和花卉中，对不同的恶性肿瘤具有化学保护和药理活性。为了提供针对各种癌症的创新管理方法，我们对木犀草素的最新发现进行了全面分析。目的是激发针对癌症的先进药物开发的新观念，并专门查找1999年1月至2024年1月发表的、研究木犀草素在各种癌症管理中的应用的有针对性的综述和研究文章。利用关键词“木犀草素”“信号通路”“癌症”和纳米颗粒在谷歌学术、科学网、Scopus、大学拨款委员会关怀列表和PubMed数据库中进行了全面的文献检索。通过对现有研究的汇编，我们发现木犀草素通过涉及NF-κB调节、AMPK/mTOR、Toll样受体、Nrf-2、PI3K/Akt MAPK和Wnt/β-连环蛋白的信号通路对各种癌症具有多种治疗作用，并且其潜在的作用机制已得到充分了解。本综述旨在全面整合有关木犀草素的天然来源、生物合成、药代动力学、信号通路、对各种癌症的化学保护和治疗特性以及纳米制剂的关键信息。
