Hecquet B, Depadt G, Fournier C, Meynadier J
Anticancer Res. 1986 Jan-Feb;6(1):65-9.
Microcapsules containing cisplatin were administered into the renal artery of mongrel dogs. Significant increase of the platinum tissue concentration in the kidney was observed 17 days after administration compared to injection of cisplatin only. The highest drug tissue levels were obtained when the renal artery was ligated after microcapsule injection. In addition the decrease in plasma levels indicated that microencapsulation causes, at least, a 100-fold enhancement of the ratio: exposure of infused tissue to the drug over total body exposure. On the contrary, no major change in drug urine excretion could be related to microencapsulation.
将含顺铂的微胶囊注入杂种犬的肾动脉。与仅注射顺铂相比，给药17天后观察到肾脏中铂组织浓度显著增加。微胶囊注射后结扎肾动脉时可获得最高的药物组织水平。此外，血浆水平的降低表明微囊化至少使以下比率提高了100倍：注入组织对药物的暴露量与全身暴露量之比。相反，药物尿排泄的主要变化与微囊化无关。
