College of Bioengineering, Chongqing University, Chongqing, 400044, China.
Chongqing Yi-Cheng Biotechnology Co., LTD, Chongqing, 400004, China.
Mol Med. 2024 Nov 14;30(1):217. doi: 10.1186/s10020-024-00978-6.
The ability to heal from wounds is perhaps the most important biological function that ensures our survival and perpetuation. Cutaneous wound healing typically consists of four characteristic stages, namely hemostasis, inflammation, proliferation, and remodeling, which are carefully carried out by coordinated actions of various cells, cytokines, and hormones. Incoordination of these steps may impede complete and efficient reconstruction and functional recovery of wounds or even lead to worsened outcomes. Hormones, as powerful modulators of organ functions, participate in multiple steps of the wound healing process and play a pivotal role by choreographing the complex interplay of cellular and molecular events. Leveraging the regulatory effects of hormones to enhance the healing process, hormonal therapy has emerged as a promising approach in the clinical treatment of wounds. Current research has focused on determination of the optimal dosages, delivery methods, and combinations of hormonal therapies to maximize their therapeutic benefits while minimizing potential side effects. This review highlights the molecular mechanisms, clinical benefits and side effects of the most commonly used hormones in clinical treatment of wounds.
从伤口中愈合的能力也许是确保我们生存和延续的最重要的生物学功能。皮肤伤口愈合通常包括四个特征性阶段，即止血、炎症、增殖和重塑，这些阶段由各种细胞、细胞因子和激素的协调作用来仔细完成。这些步骤的不协调可能会阻碍伤口的完全和有效重建以及功能恢复，甚至导致结果恶化。激素作为器官功能的强大调节剂，参与伤口愈合过程的多个步骤，并通过协调细胞和分子事件的复杂相互作用发挥关键作用。利用激素的调节作用来增强愈合过程，激素治疗已成为治疗伤口的一种有前途的方法。目前的研究集中在确定激素治疗的最佳剂量、给药方法和组合，以最大限度地提高其治疗益处，同时最小化潜在的副作用。本综述强调了在临床治疗伤口中最常用的激素的分子机制、临床益处和副作用。
