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新修订的 IASLC 提出的浸润性肺腺癌分级系统对预后的影响：系统评价和荟萃分析。

Prognostic impact of the newly revised IASLC proposed grading system for invasive lung adenocarcinoma: a systematic review and meta-analysis.

机构信息

Department of Thoracic Surgery, The First People's Hospital of Jiande, Jiande, China.

Department of Thoracic Surgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

出版信息

World J Surg Oncol. 2024 Nov 14;22(1):302. doi: 10.1186/s12957-024-03584-2.

DOI:10.1186/s12957-024-03584-2
PMID:39543564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11566641/
Abstract

BACKGROUND

This study aimed to evaluate the prognostic value of the newly revised International Association for the Study of Lung Cancer (IASLC) grading system (2020) on the 5-year overall survival (OS) and recurrence-free survival (RFS) in patients with lung adenocarcinoma (LADC).

METHODS

Clinical studies that investigated the prognostic value of revised IASLC staging system in patients with LADC were retrieved from the PubMed, Web of Science, ScienceDirect, and Cochrane Library databases. This study was conducted in accordance to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and checklists.

RESULTS

Based on inclusion and exclusion criteria, we included 12 studies for analysis. The grade of LADC was assessed by revised IASLC system, which included three grades. Compared to Grade 3 LADC, grade 1 (total [95% CI]: 1.38 [1.19, 1.60]) and grade 2 (total [95% CI]: 1.29 [1.15, 1.44]) LADC had higher 5-year OS rates. Similarly, Grade 1 (total [95% CI]: 1.76 [1.42, 2.18]) and Grade 2 (total [95% CI]: 1.51 [1.28, 1.77]) had higher 5-year RFS rates Grade 3 LADC. However, 5-year OS and RFS had no significant difference between Grade 1 and Grade 2 patients.

CONCLUSION

This systematic review and meta-analysis provides evidence that the newly revised IASLC grading system is significantly associated with the prognosis of patients with LADC, where Grade 3 indicated unfavorable prognosis.

摘要

背景

本研究旨在评估新修订的国际肺癌研究协会（IASLC）分级系统（2020 年）对肺腺癌（LADC）患者 5 年总生存（OS）和无复发生存（RFS）的预后价值。

方法

从 PubMed、Web of Science、ScienceDirect 和 Cochrane Library 数据库中检索评估新修订的 IASLC 分期系统对 LADC 患者预后价值的临床研究。本研究按照 2020 年系统评价和荟萃分析的首选报告项目（PRISMA）指南和清单进行。

结果

根据纳入和排除标准，我们纳入了 12 项研究进行分析。LADC 的分级采用修订后的 IASLC 系统进行评估，包括三个等级。与 3 级 LADC 相比，1 级（总[95%CI]：1.38[1.19, 1.60]）和 2 级（总[95%CI]：1.29[1.15, 1.44]）LADC 的 5 年 OS 率更高。同样，1 级（总[95%CI]：1.76[1.42, 2.18]）和 2 级（总[95%CI]：1.51[1.28, 1.77]）的 5 年 RFS 率也更高。然而，3 级和 1 级、2 级之间的 5 年 OS 和 RFS 无显著差异。

结论

本系统评价和荟萃分析提供的证据表明，新修订的 IASLC 分级系统与 LADC 患者的预后显著相关，其中 3 级表示预后不良。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/aa3d4d70b137/12957_2024_3584_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/e1712e78a667/12957_2024_3584_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/c090eeef4a3c/12957_2024_3584_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/72d35c83b804/12957_2024_3584_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/637d44f2a0fc/12957_2024_3584_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/b3cd593c9c22/12957_2024_3584_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/cbae22fbe2f1/12957_2024_3584_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/fd609a8903b1/12957_2024_3584_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/c7c6b92bb174/12957_2024_3584_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/0a6ef5f2fd94/12957_2024_3584_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/aa3d4d70b137/12957_2024_3584_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/e1712e78a667/12957_2024_3584_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/c090eeef4a3c/12957_2024_3584_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/72d35c83b804/12957_2024_3584_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/637d44f2a0fc/12957_2024_3584_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/b3cd593c9c22/12957_2024_3584_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/cbae22fbe2f1/12957_2024_3584_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/fd609a8903b1/12957_2024_3584_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/c7c6b92bb174/12957_2024_3584_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/0a6ef5f2fd94/12957_2024_3584_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8372/11566641/aa3d4d70b137/12957_2024_3584_Fig10_HTML.jpg

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