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免疫动力学塑造肝转移中的前转移和转移生态位：从分子机制到治疗策略。

Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies.

机构信息

Hepatic Surgery Center, and Hubei Province for the Clinical Medicine Research Center of Hepatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China.

Hubei Key Laboratory of Hepato-Pancreatic-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P. R. China.

出版信息

Mol Cancer. 2024 Nov 14;23(1):254. doi: 10.1186/s12943-024-02171-z.

DOI:10.1186/s12943-024-02171-z
PMID:39543660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11562679/
Abstract

Liver metastases are commonly detected in the advanced stages of various malignant tumors, representing a significant clinical challenge. Throughout the process of liver metastases formation, immune cells play a pivotal role, particularly in the pre-metastatic and metastatic niches within the liver. Immune cells establish extensive and intricate interactions with tumor cells and other components in the liver, collectively promoting and sustaining the growth of liver metastases. Despite the limited efficacy of existing therapeutic modalities against some advanced liver metastases, novel immune-based treatment approaches are continuously being explored and validated. Building on the systematic elucidation of the immunosuppressive characteristics of liver metastases, we explored the potential of novel immunotherapies applicable to patients with liver metastases from multiple dimensions.

摘要

肝转移在各种恶性肿瘤的晚期通常被检测到，这是一个重大的临床挑战。在肝转移形成的整个过程中，免疫细胞发挥着关键作用，特别是在肝内的前转移和转移龛位中。免疫细胞与肿瘤细胞和肝内的其他成分建立了广泛而复杂的相互作用，共同促进和维持肝转移的生长。尽管现有的治疗方法对某些晚期肝转移的疗效有限，但仍在不断探索和验证新的基于免疫的治疗方法。基于对肝转移免疫抑制特征的系统阐述，我们从多个维度探讨了适用于肝转移患者的新型免疫疗法的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/c1aed515b195/12943_2024_2171_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/71393af9a00c/12943_2024_2171_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/c444e2f0ccaa/12943_2024_2171_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/f77abbfdbd8c/12943_2024_2171_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/0eb0d982acbb/12943_2024_2171_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/63c198b76425/12943_2024_2171_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/c1aed515b195/12943_2024_2171_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/71393af9a00c/12943_2024_2171_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/c444e2f0ccaa/12943_2024_2171_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/f77abbfdbd8c/12943_2024_2171_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/0eb0d982acbb/12943_2024_2171_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/63c198b76425/12943_2024_2171_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7546/11562679/c1aed515b195/12943_2024_2171_Fig6_HTML.jpg

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Immune dynamics shaping pre-metastatic and metastatic niches in liver metastases: from molecular mechanisms to therapeutic strategies.

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引用本文的文献

[1]
Liver metastasis of colorectal cancer: Mechanism and clinical therapy (Review).

Oncol Rep. 2025-10

[2]
Consensus Guideline of Ablation for Metastatic Liver Tumors by Taiwan Academy of Tumor Ablation.

Liver Cancer. 2025-6-19

[3]
Metastatic hepatic carcinoma: Mechanisms, emerging therapeutics, and future perspectives.

iScience. 2025-6-14

[4]
A dual-targeting strategy to inhibit colorectal cancer liver metastasis via tumor cell ferroptosis and cancer-associated fibroblast reprogramming.

Bioact Mater. 2025-6-5

[5]
Global hotspots and trends in pre-metastatic niche research: a bibliometric analysis(2005-2024).

Front Immunol. 2025-5-29

[6]
Single-cell profiling uncovers the intricate pathological niche diversity in brain, lymph node, bone, and adrenal metastases of lung cancer.

Discov Oncol. 2025-4-10

[7]
Efficacy and safety of sintilimab plus bevacizumab and CAPOX as first-line treatment for patients with RAS-mutant, microsatellite stable, metastatic colorectal cancer.

BMC Cancer. 2025-3-7

本文引用的文献

[1]
Pre-metastatic niche: formation, characteristics and therapeutic implication.

Signal Transduct Target Ther. 2024-9-25

[2]
New Insights into the Exosome-Induced Migration of Uveal Melanoma Cells and the Pre-Metastatic Niche Formation in the Liver.

Cancers (Basel). 2024-8-27

[3]
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-.

Acta Pharm Sin B. 2024-8

[4]
Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1CD206 pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.

Mol Cancer. 2024-8-20

[5]
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis.

Cancer Cell. 2024-8-12

[6]
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors.

Cell Mol Immunol. 2024-10

[7]
Necroptosis enhances 'don't eat me' signal and induces macrophage extracellular traps to promote pancreatic cancer liver metastasis.

Nat Commun. 2024-7-18

[8]
Metabolic reprogramming in liver fibrosis.

Cell Metab. 2024-7-2

[9]
Establishment of a neutrophil extracellular trap-related prognostic signature for colorectal cancer liver metastasis and expression validation of CYP4F3.

Clin Exp Med. 2024-5-25

[10]
Immune Cell Migration to Cancer.

Cells. 2024-5-16

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