Shimizu S, Katayama K, Matsukawa H, Gotoh H, Matsumoto A, Yokoyama H, Suda T, Gotoh H, Arita M, Jojima T
Gan To Kagaku Ryoho. 1986 Mar;13(3 Pt 1):590-2.
For the purpose of local therapy for advanced and recurrent breast cancer, we have applied a new Adriamycin (ADR) ointment. This new ADR ointment has been prepared by the technique of a two-factor composite experimental design and includes PEG: 25%, CVP: 0.65%, HPC: 1.35% and ADR: 0.04%. We have applied it to three patients with advanced breast cancer and six patients with locally recurrent breast cancer. By using this ointment, the skin ulcers have become dry, bleeding has stopped and the sense of heat has been lost. In some cases, the neoplastic ulcers have diminished in size. Some problems with this ointment are easy bleeding at the time of removing the gauze and an unstable effect in diminishing the size of the neoplasm. We therefore think that the use of this ointment alone is very effective for controlling the symptoms of the local lesion, but not so effective for diminishing the size of the neoplasm.
为了对晚期和复发性乳腺癌进行局部治疗，我们应用了一种新的阿霉素（ADR）软膏。这种新的ADR软膏是通过双因素复合实验设计技术制备的，其成分包括聚乙二醇（PEG）：25%、环磷酰胺（CVP）：0.65%、羟丙基纤维素（HPC）：1.35%以及阿霉素（ADR）：0.04%。我们已将其应用于3例晚期乳腺癌患者和6例局部复发性乳腺癌患者。使用这种软膏后，皮肤溃疡变干，出血停止，热感消失。在某些情况下，肿瘤性溃疡的大小有所减小。这种软膏存在一些问题，如去除纱布时容易出血，以及在减小肿瘤大小方面效果不稳定。因此，我们认为单独使用这种软膏对于控制局部病变症状非常有效，但在减小肿瘤大小方面效果欠佳。
