Chandrasekar Bhargavi, Bell Alexandra, Kinshuck Andrew
ENT Department, Liverpool Head and Neck Centre, Liverpool University Hospital Foundation Trust, Liverpool, UK.
J Laryngol Otol. 2025 Jun;139(6):507-511. doi: 10.1017/S0022215124002172.
The aim of this study was to evaluate the rate of dysplasia and carcinoma-ex-papillomatosis in patients with recurrent respiratory papillomatosis and assess for any risk factors.
A 15-year retrospective observational cohort study was performed from a single centre. Data on patient demographics, treatment history and pathology results were extracted from clinical records.
Of the 123 patients identified, nine had juvenile-onset recurrent respiratory papillomatosis and 114 had adult-onset recurrent respiratory papillomatosis. Thirteen (11 per cent) of patients with adult-onset recurrent respiratory papillomatosis had dysplasia, and one patient progressed to carcinoma-ex-papillomatosis. Patients with evidence of dysplasia had an average older age of disease onset compared to those without dysplasia (49 years 39 years, = 0.03).
An older age of recurrent respiratory papillomatosis onset was the only risk factor for dysplasia. Gender, tobacco use, subglottic or tracheal involvement, number of surgeries and cidofovir were not prognostic factors in this series.
本研究旨在评估复发性呼吸道乳头状瘤病患者的发育异常率和乳头状瘤病恶变率，并评估相关危险因素。
在单一中心开展了一项为期15年的回顾性观察队列研究。从临床记录中提取患者人口统计学数据、治疗史和病理结果。
在确定的123例患者中，9例为青少年型复发性呼吸道乳头状瘤病，114例为成人型复发性呼吸道乳头状瘤病。114例成人型复发性呼吸道乳头状瘤病患者中有13例（11%）出现发育异常，1例进展为乳头状瘤病恶变。与未出现发育异常的患者相比，出现发育异常的患者疾病发病平均年龄更大（49岁对39岁，P = 0.03）。
复发性呼吸道乳头状瘤病发病年龄较大是发育异常的唯一危险因素。在本系列研究中，性别、吸烟情况、声门下或气管受累情况、手术次数和西多福韦均不是预后因素。
