Cuidado Cardiorrespiratorio Research Group, Universidad Manuela Beltrán, Bogotá, Colombia.
Grupo de investigación Biodiversidad para la Sociedad, Dirección Académica, Universidad Nacional de Colombia, Sede De La Paz, La Paz, Cesar, Colombia.
PLoS One. 2024 Nov 15;19(11):e0300826. doi: 10.1371/journal.pone.0300826. eCollection 2024.
Although moderate and severe Covid-19 patients have shown obstructive and restrictive disorders in pulmonary function after recovery from the disease, studies evaluating the effectiveness of rehabilitation programs that seek to improve lung function are scarce.
Herein, we evaluate changes in lung function and perceived dyspnea in Covid-19 patients after undergoing 12 weeks of a pulmonary rehabilitation (PR) program.
Retrospective observational study.
Cesar, Colombia Neumocesar Pneumological Center.
100 outpatients with a history of Covid-19.
Respiratory function using spirometry parameters, as well as perceived dyspnea, measured by the modified Medical Research Council (mMRC) dyspnea scale, was evaluated in 100 patients with a history of Covid-19. We used univariate and multivariate statistical approaches to assess changes in lung function and perceived dyspnea before and after a PR program to determine whether gender, age, height, weight, comorbidities, and oxygen delivery system affects the recovery of lung function and perceived dyspnea.
It was found that PR treatment has positive effects on respiratory pathologies caused by SARS-CoV-2 infection regardless of patient gender (S = 0,029), indicating that rehabilitation provided benefits regardless of the physical characteristics of the patients. Both univariate and multivariate statistical analyses indicated that FVC (P = 0,0001), FEV1(P = 0,0001), and mMRC (P = 0,0001) are robust diagnostic indicators of lung function recovery and perceived dyspnea. Both invasive and non-invasive positive pressure ventilatory support had deleterious effects on lung function prolongating patient recovery (P = 0,0001).
Rehabilitation programs can benefit patients facing respiratory pathologies caused by SARS-CoV-2 infection. Additional research on the long-term effects of the sequelae of Covid-19 is needed.
PR programs have positive effects on patients facing respiratory pathologies caused by SARS-CoV-2 infection.
尽管患有中度和重度 COVID-19 的患者在从疾病中康复后表现出肺功能的阻塞性和限制性障碍，但评估旨在改善肺功能的康复计划效果的研究很少。
在此，我们评估 COVID-19 患者在接受 12 周肺康复（PR）计划后肺功能和呼吸困难感知的变化。
回顾性观察性研究。
哥伦比亚凯撒 Neumocesar 肺科中心。
100 名有 COVID-19 病史的门诊患者。
使用肺活量计参数评估呼吸功能，以及通过改良的医学研究委员会（mMRC）呼吸困难量表评估呼吸困难感知。我们使用单变量和多变量统计方法来评估 PR 计划前后肺功能和呼吸困难感知的变化，以确定性别、年龄、身高、体重、合并症和氧气输送系统是否影响肺功能和呼吸困难感知的恢复。
发现 PR 治疗对 SARS-CoV-2 感染引起的呼吸道疾病有积极影响，无论患者性别如何（S = 0.029），这表明康复对患者的身体特征没有影响。单变量和多变量统计分析均表明，FVC（P = 0.0001）、FEV1（P = 0.0001）和 mMRC（P = 0.0001）是肺功能恢复和呼吸困难感知的稳健诊断指标。有创和无创正压通气支持对肺功能均有不利影响，延长了患者的恢复时间（P = 0.0001）。
康复计划可以使 SARS-CoV-2 感染引起的呼吸道疾病患者受益。需要进一步研究 COVID-19 后遗症的长期影响。
PR 计划对 SARS-CoV-2 感染引起的呼吸道疾病患者有积极影响。
