Tsuboi S, Pederson J E
Arch Ophthalmol. 1986 Apr;104(4):602-3. doi: 10.1001/archopht.1986.01050160158033.
Rhegmatogenous retinal detachments were created in one eye of each of six cynomolgus monkeys. Total vitrectomy alone was performed in the fellow eyes. The rate of disappearance of fluorescein sodium injected into the vitreous cavity was measured with kinetic vitreous fluorophotometry. Intravitreal 10(-4)M probenecid was used to inhibit active outward transport of fluorescein. In eyes with retinal detachment, the rate of fluorescein loss from the vitreous cavity was decreased 44% and 22% following intravitreal injection of 10(-4) and 10(-5)M furosemide (Lasix), respectively. Intravitreal 10(-4)M furosemide decreased the rate of fluorescein loss in fellow eyes by 35%. The rate of fluorescein loss via the anterior chamber accounted for only 1% to 8% of the total rate of vitreous fluorescein loss. Thus, it is concluded that intravitreal absorption across the retinal pigment epithelium.
在六只食蟹猴的每只猴子的一只眼睛中造成孔源性视网膜脱离。对另一只眼睛仅进行全玻璃体切除术。用动态玻璃体荧光光度法测量注入玻璃体腔的荧光素钠的消失率。玻璃体内使用10(-4)M丙磺舒来抑制荧光素的主动外向转运。在视网膜脱离的眼睛中，玻璃体内注射10(-4)M和10(-5)M速尿（速尿）后，玻璃体腔中荧光素的损失率分别降低了44%和22%。玻璃体内10(-4)M速尿使另一只眼睛中荧光素的损失率降低了35%。通过前房的荧光素损失率仅占玻璃体荧光素总损失率的1%至8%。因此，得出结论，玻璃体内的吸收是通过视网膜色素上皮进行的。
