Webb R F, Ottaway S J
Aust Vet J. 1986 Jan;63(1):13-6. doi: 10.1111/j.1751-0813.1986.tb02863.x.
A survey was undertaken to assess the prevalence of anthelmintic resistance in sheep nematode populations on 40 commercial farms distributed throughout the central tablelands of New South Wales. Representatives of the 2 major groups of broad spectrum anthelmintics with different modes of action (thiabendazole and levamisole) were used at the manufacturer's recommended dose rates. Efficacy was assessed on the basis of the reduction in faecal strongyle egg counts 7 days after treatment. An efficacy of less than 90% using both anthelmintics was obtained on 4 farms. Thiabendazole had an efficacy of less than 90% on a further 21 farms and levamisole had an efficacy of less than 90% on an additional 4 farms. There was no evidence of anthelmintic resistance on 8 farms, while the remaining 3 had insignificant parasite burdens. Based on larval cultures from faeces, Ostertagia and Trichostrongylus were the most significant species in resistant populations. Haemonchus burdens were sporadic and levels of resistance relatively low. Nematodirus burdens were widespread but no evidence of resistance was detected.
在新南威尔士州中部高地分布的40个商业农场开展了一项调查，以评估绵羊线虫种群中抗蠕虫药耐药性的流行情况。使用了具有不同作用方式的2类主要广谱抗蠕虫药（噻苯达唑和左旋咪唑）的代表药物，并按照制造商推荐的剂量率给药。根据治疗7天后粪便中圆线虫卵数量的减少情况评估疗效。在4个农场中，两种抗蠕虫药的疗效均低于90%。噻苯达唑在另外21个农场的疗效低于90%，左旋咪唑在另外4个农场的疗效低于90%。在8个农场没有抗蠕虫药耐药性的证据，而其余3个农场的寄生虫负担微不足道。根据粪便幼虫培养结果，奥斯特他线虫属和毛圆线虫属是耐药种群中最重要的种类。血矛线虫的负担是零星的，耐药水平相对较低。细颈线虫的负担普遍存在，但未检测到耐药性证据。
