Tong Juan, Liang Chunmei, Tao Shuman, Wang Xing, Gan Hong, Zhou Jixing, Geng Menglong, Yan Shuangqin, Gao Guopeng, Jiang Liu, Wu Xiaoyan, Huang Kun, Tao Fangbiao
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, 230032, Anhui, China.
Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei, 230032, Anhui, China; MOE Key Laboratory of Population Health Across Life Cycle, No 81 Meishan Road, Hefei, 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei, 230032, Anhui, China.
Environ Res. 2025 Jan 1;264(Pt 1):120366. doi: 10.1016/j.envres.2024.120366. Epub 2024 Nov 14.
The increasing role of environmental pollutants and nutrients in the development of myopia. Further longitudinal evidence is needed to elucidate the effects of early-life environmental pollutants on myopia and nutrients to protect against pollutant-induced myopia. We used mother-child dyads from the Ma'anshan Birth Cohort (n = 2028) to explore the modifying effects of maternal vitamin D status of prenatal and childhood arsenic exposure with refractive parameters and myopia. We measured serum or plasma arsenic concentrations during three trimesters, in cord blood, in childhood (5-year-old), and performed cycloplegic refraction in children aged 7-9 years (n = 1616). Primary outcomes were myopia and refractive parameters including axial length (AL), corneal radius of curvature, and spherical equivalent refraction error. Linear regression, logistic regression, and multiple informant models were performed for the association of prenatal and childhood arsenic exposure with vision health. Sex- and vitamin D status stratification analyses were also conducted. Cord serum arsenic was positively associated with AL (β = 0.15, 95%CI: 0.01, 0.29) and the risk of developing myopia (OR = 1.72, 95%CI: 1.07,， 2.75). Among boys, a 1 ng/L increase in cord serum log-transformed arsenic resulted in larger AL and a higher risk of myopia. In the vitamin D deficient group (<20 ng/mL), cord serum arsenic showed positive associations with AL (0.26 [0.06, 0.46]) and the risk of myopia (1.99 [1.01, 3.90]). Late pregnancy arsenic exposure likely affects offspring development of myopia, especially in boys. Maternal sufficient vitamin D may confer protective effects against the development of myopia.
环境污染物和营养物质在近视发展中日益重要的作用。需要进一步的纵向证据来阐明早期环境污染物对近视的影响以及营养物质对预防污染物诱发近视的作用。我们利用马鞍山出生队列中的母婴二元组（n = 2028）来探讨母亲维生素D状态对产前和儿童期砷暴露与屈光参数及近视的调节作用。我们在孕期三个阶段、脐带血、儿童期（5岁）测量了血清或血浆砷浓度，并对7至9岁儿童（n = 1616）进行了散瞳验光。主要结局指标为近视和屈光参数，包括眼轴长度（AL）、角膜曲率半径和等效球镜屈光不正。对产前和儿童期砷暴露与视力健康的关联进行了线性回归、逻辑回归和多信息源模型分析。还进行了性别和维生素D状态分层分析。脐带血清砷与AL呈正相关（β = 0.15，95%CI：0.01，0.29）以及患近视的风险（OR = 1.72，95%CI：1.07，2.75）。在男孩中，脐带血清对数转换砷每增加1 ng/L会导致更大的AL和更高的近视风险。在维生素D缺乏组（<20 ng/mL）中，脐带血清砷与AL（0.26 [0.06，0.46]）和近视风险（1.99 [1.01，3.90]）呈正相关。妊娠晚期砷暴露可能影响后代近视的发展，尤其是男孩。母亲充足的维生素D可能对近视的发展具有保护作用。
