Song Yu-Ting, Liu Peng-Cheng, Zhou Xing-Li, Chen Yan-Ming, Wu Wu, Zhang Ji-Ye, Li-Ling Jesse, Xie Hui-Qi
Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Department of Orthopedic Surgery and Orthopedic Research Institute, Stem Cell and Tissue Engineering Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Int J Biol Macromol. 2024 Dec;283(Pt 3):137633. doi: 10.1016/j.ijbiomac.2024.137633. Epub 2024 Nov 15.
Burns are common traumatic injuries affecting many people worldwide. Development of specialized burn units, advances in acute care modalities, and burn prevention programs have successfully reduced the mortality rate of severe burns. Autologous skin grafting has been considered as the gold standard for wound coverage after the removal of burned skin. For full-thickness burns of a larger scale, however, the autograft donor site may be quickly exhausted, so that alternative skin coverage is necessary. Although rapid progress has been made in the development of skin substitutes for burn wounds during the last decade, no skin substitute has fulfilled the criteria as a perfect replacement for the damaged skin. Extracellular matrix (ECM) derived components have emerged as a source for the engineering of biomaterials capable of inducing desirable cell-specific responses and one of the most promising biomaterials for burn wound healing. Among these, acellular dermal matrix, small intestinal submucosa, and amniotic membrane have been applied to treat burn wounds with acceptable outcomes. This review has explored the use of biomaterials derived from naturally occurring ECM and their derivatives for approaches aiming to promote burn wound healing, and summarized the ECM-based wound dressings products applicable in burn wound and postburn scar contracture to date.
烧伤是常见的创伤性损伤,影响着全球许多人。专门烧伤病房的发展、急性护理模式的进步以及烧伤预防项目已成功降低了严重烧伤的死亡率。自体皮肤移植一直被视为去除烧伤皮肤后伤口覆盖的金标准。然而,对于较大面积的全层烧伤,自体移植供区可能会很快耗尽,因此需要替代的皮肤覆盖物。尽管在过去十年中烧伤创面皮肤替代物的开发取得了快速进展,但尚无一种皮肤替代物能满足作为受损皮肤完美替代品的标准。源自细胞外基质(ECM)的成分已成为工程化生物材料的来源,这些生物材料能够诱导理想的细胞特异性反应,是烧伤创面愈合最有前景的生物材料之一。其中,脱细胞真皮基质、小肠黏膜下层和羊膜已被用于治疗烧伤创面,效果尚可。本综述探讨了源自天然ECM及其衍生物的生物材料在促进烧伤创面愈合方法中的应用,并总结了迄今为止适用于烧伤创面和烧伤后瘢痕挛缩的基于ECM的伤口敷料产品。