Liu Yun, Zhang Xu, Yi Ruhan, Tian Qing, Xu Jiawei, Yan Xinyu, Ma Jiaxuan, Wang Shaopeng, Yang Guang
Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian, 116044, China.
Department of Cardiology, The First Affiliated Hospital of Dalian Medical University, Dalian, 116011, China.
Chem Biol Interact. 2025 Jan 5;405:111310. doi: 10.1016/j.cbi.2024.111310. Epub 2024 Nov 15.
Di-2-ethylhexyl phthalate (DEHP), a widely applied plasticizer in various products, can be absorbed into the human body through several channels and accumulate in the lungs, liver, testes, and kidneys, potentially impairing the function of these organs. Recently, the nephrotoxicity of DEHP has received heightened attention. Numerous epidemiologic findings have demonstrated that DEHP exposure may contribute to renal damage, leading to structural and functional abnormalities and exacerbating the progression of kidney disease. Recent research has discovered the mechanisms behind DEHP-induced nephrotoxicity may involve a variety of pathways, including apoptosis, autophagy, ferroptosis, oxidative stress, inflammation, DNA damage, and lipid metabolism disorders. This review discusses the impact of DEHP on kidney function and delves into the molecular mechanisms of nephrotoxicity mediated by DEHP in recent years. In addition, the review examines evidence for the antioxidant and anti-inflammatory capacities of lycopene, green tea polyphenols, and quercetin in ameliorating DEHP-induced renal injury is reviewed, providing a basis for further research.
邻苯二甲酸二（2-乙基己基）酯（DEHP）是一种在各种产品中广泛应用的增塑剂，可通过多种途径被人体吸收，并在肺、肝、睾丸和肾脏中蓄积，可能损害这些器官的功能。近年来，DEHP的肾毒性受到了更多关注。大量流行病学研究结果表明，接触DEHP可能导致肾脏损伤，引起结构和功能异常，并加剧肾脏疾病的进展。最近的研究发现，DEHP诱导肾毒性的机制可能涉及多种途径，包括细胞凋亡、自噬、铁死亡、氧化应激、炎症、DNA损伤和脂质代谢紊乱。本文综述了DEHP对肾功能的影响，并深入探讨了近年来DEHP介导的肾毒性分子机制。此外，本文还综述了番茄红素、绿茶多酚和槲皮素在改善DEHP诱导的肾损伤方面的抗氧化和抗炎能力的证据，为进一步研究提供依据。
