Nampoothiri Vrinda, Hisham Mohamed, Mbamalu Oluchi, Mohamed Zubair Umer, Singh Sanjeev K, Charani Esmita
Department of Health Sciences Research, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Department of Pharmacy Services, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Int J Infect Dis. 2025 Feb;151:107306. doi: 10.1016/j.ijid.2024.107306. Epub 2024 Nov 16.
Whilst pharmacists are recognized as key contributors to antimicrobial stewardship (AMS) programs, the extent of their participation varies in different countries. We report a systematic review of pharmacist roles in AMS over 20 years.
A systematic review of the literature describing pharmacist-led or driven AMS and its outcomes published in English between January 01, 2000, and June 30, 2020, was conducted across the main databases for research publication.
The analysis included 111 papers, of which 77.5% (86/111) were from high-income countries (HIC) predominantly from the USA. While pharmacist-led or driven AMS interventions were reported only from HICs in the early 2000s, the review found a progressive rise in such studies from all income settings with audit and feedback being the most frequent intervention reported. Between 2016 and 2020, studies on pharmacists-led or driven outpatient AMS and interventions related to beta-lactam or penicillin allergy were reported from HICs. Key outcomes reported include improved appropriateness of antimicrobial therapy and decreased consumption of antimicrobials.
Existing evidence demonstrates the positive impact of pharmacists' involvement in AMS. There needs to be a concerted effort in facilitating pharmacist roles in AMS across all countries, irrespective of income setting.
虽然药剂师被认为是抗菌药物管理（AMS）项目的关键贡献者，但他们在不同国家的参与程度各不相同。我们报告了对20年来药剂师在AMS中的角色进行的系统评价。
对2000年1月1日至2020年6月30日期间以英文发表的描述药剂师主导或推动的AMS及其结果的文献进行系统评价，检索了主要的研究出版物数据库。
分析纳入了111篇论文，其中77.5%（86/111）来自高收入国家（HIC），主要是美国。虽然在21世纪初只有高收入国家报告了药剂师主导或推动的AMS干预措施，但该评价发现所有收入水平的此类研究都在逐渐增加，审计和反馈是报告最频繁的干预措施。2016年至2020年期间，高收入国家报告了关于药剂师主导或推动的门诊AMS以及与β-内酰胺或青霉素过敏相关的干预措施。报告的主要结果包括抗菌治疗的适宜性提高和抗菌药物消耗减少。
现有证据表明药剂师参与AMS具有积极影响。需要共同努力，促进所有国家的药剂师在AMS中的作用，无论其收入水平如何。
