Jansson T, Thordstein M, Kjellmer I
Biol Neonate. 1986;49(3):172-80. doi: 10.1159/000242528.
Placental blood flow (microsphere distribution), placental weight and fetal weight were examined at three stages of gestation following unilateral uterine artery ligation at days 30-32 in 23 guinea pigs. Placental blood flow and placental weight were reduced in the ligated horn at days 45, 55, and 65. The fetal weight was decreased at days 55 and 65. We suggest that ligation of the uterine artery reduces placental blood flow which, in turn, restricts placental growth without any significant effect on fetal weight before day 45. At this stage of gestation no correlation was found between fetal weight and placental blood flow. Later in gestation, however, fetal growth becomes limited by placental blood flow, and between days 45 and 55 ligation impedes the increase in blood flow, and consequently the fetal growth rate declines.
在23只豚鼠妊娠第30 - 32天对其单侧子宫动脉进行结扎，之后在妊娠的三个阶段检查胎盘血流量（微球分布）、胎盘重量和胎儿重量。在妊娠第45、55和65天时，结扎侧子宫角的胎盘血流量和胎盘重量降低。在妊娠第55和65天时胎儿体重下降。我们认为，子宫动脉结扎会减少胎盘血流量，进而限制胎盘生长，在妊娠第45天之前对胎儿体重无显著影响。在此妊娠阶段，未发现胎儿体重与胎盘血流量之间存在相关性。然而，在妊娠后期，胎儿生长受到胎盘血流量的限制，在妊娠第45至55天期间，结扎会阻碍血流量增加，因此胎儿生长速率下降。
