Zaccarelli-Magalhães Julia, Citadin Cristiane Teresinha, Langman Julia, Smith Drew James, Matuguma Luiz Henrique, Lin Hung Wen, Udo Mariana Sayuri Berto
Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Department of Neurology, McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA.
Exp Neurol. 2025 Feb;384:115060. doi: 10.1016/j.expneurol.2024.115060. Epub 2024 Nov 17.
Arginine modification can be a "switch" to regulate DNA transcription and a post-translational modification via methylation of a variety of cellular targets involved in signal transduction, gene transcription, DNA repair, and mRNA alterations. This consequently can turn downstream biological effectors "on" and "off". Arginine methylation is catalyzed by protein arginine methyltransferases (PRMTs 1-9) in both the nucleus and cytoplasm, and is thought to be involved in many disease processes. However, PRMTs have not been well-documented in the brain and their function as it relates to metabolism, circulation, functional learning and memory are understudied. In this review, we provide a comprehensive overview of PRMTs relevant to cellular stress, and future directions into PRMTs as therapeutic regulators in brain pathologies.
精氨酸修饰可以作为一种“开关”来调节DNA转录，并且是一种通过甲基化参与信号转导、基因转录、DNA修复和mRNA改变的多种细胞靶点的翻译后修饰。因此，这可以开启和关闭下游生物效应器。精氨酸甲基化由细胞核和细胞质中的蛋白质精氨酸甲基转移酶（PRMTs 1 - 9）催化，并且被认为参与许多疾病过程。然而，PRMTs在大脑中的相关记录并不完善，其与代谢、循环、功能学习和记忆相关的功能也研究不足。在这篇综述中，我们全面概述了与细胞应激相关的PRMTs，以及PRMTs作为脑病理学治疗调节剂的未来研究方向。
