Wolf S S
Bayer Schering Pharma AG, Global Drug Discovery, TRG Women's Healthcare, Muellerstr 178, 13353, Berlin, Germany.
Cell Mol Life Sci. 2009 Jul;66(13):2109-21. doi: 10.1007/s00018-009-0010-x. Epub 2009 Mar 20.
Information about the family of protein arginine methyltransferases (PRMTs) has been growing rapidly over the last few years and the emerging role of arginine methylation involved in cellular processes like signaling, RNA processing, gene transcription, and cellular transport function has been investigated. To date, 11 PRMTs gene transcripts have been identified in humans. Almost all PRMTs have been shown to have enzymatic activity and to catalyze arginine methylation. This review will summarize the overall function of human PRMTs and include novel highlights on each family member.
在过去几年中,关于蛋白质精氨酸甲基转移酶(PRMTs)家族的信息增长迅速,人们已经对精氨酸甲基化在信号传导、RNA加工、基因转录和细胞运输功能等细胞过程中所起的新作用进行了研究。迄今为止,已在人类中鉴定出11种PRMTs基因转录本。几乎所有的PRMTs都已被证明具有酶活性并能催化精氨酸甲基化。本综述将总结人类PRMTs的整体功能,并介绍每个家族成员的新亮点。