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Can we modulate the gut microbiome to enhance DMARD efficacy in rheumatoid arthritis?

作者信息

Blank Rebecca B, Nayak Renuka R, Scher Jose U

机构信息

Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, USA.

Rheumatology Division, Department of Medicine, University of California, San Francisco, CA, USA.

出版信息

Semin Arthritis Rheum. 2025 Feb;70S:152583. doi: 10.1016/j.semarthrit.2024.152583. Epub 2024 Nov 10.

Abstract
摘要

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本文引用的文献

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Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.
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participates in the therapeutic effect of methotrexate on arthritis through metabolite regulation.
Front Microbiol. 2022 Dec 15;13:1015130. doi: 10.3389/fmicb.2022.1015130. eCollection 2022.
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Front Immunol. 2021 Dec 3;12:796865. doi: 10.3389/fimmu.2021.796865. eCollection 2021.
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The gut-joint axis in rheumatoid arthritis.
Nat Rev Rheumatol. 2021 Apr;17(4):224-237. doi: 10.1038/s41584-021-00585-3. Epub 2021 Mar 5.
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Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Cell Host Microbe. 2021 Mar 10;29(3):362-377.e11. doi: 10.1016/j.chom.2020.12.008. Epub 2021 Jan 12.
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The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.
Arthritis Rheumatol. 2021 Jun;73(6):931-942. doi: 10.1002/art.41622. Epub 2021 May 2.

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