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Can we modulate the gut microbiome to enhance DMARD efficacy in rheumatoid arthritis?我们能否调节肠道微生物群以提高类风湿性关节炎中改善病情抗风湿药的疗效？
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Biologics or tofacitinib for rheumatoid arthritis in incomplete responders to methotrexate or other traditional disease-modifying anti-rheumatic drugs: a systematic review and network meta-analysis.生物制剂或托法替布用于对甲氨蝶呤或其他传统改善病情抗风湿药物反应不完全的类风湿关节炎患者：一项系统评价和网状Meta分析
Cochrane Database Syst Rev. 2016 May 13;2016(5):CD012183. doi: 10.1002/14651858.CD012183.
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Role of the intestinal flora-immunity axis in the pathogenesis of rheumatoid arthritis-mechanisms regulating short-chain fatty acids and Th17/Treg homeostasis.肠道菌群-免疫轴在类风湿关节炎发病机制中的作用——调节短链脂肪酸和Th17/Treg稳态的机制
Mol Biol Rep. 2025 Jun 21;52(1):617. doi: 10.1007/s11033-025-10714-w.
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Gut microbiome-based interventions for the management of obesity in children and adolescents aged up to 19 years.基于肠道微生物群的干预措施用于管理19岁及以下儿童和青少年的肥胖问题。
Cochrane Database Syst Rev. 2025 Jul 10;7(7):CD015875. doi: 10.1002/14651858.CD015875.
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Immunomodulatory properties of the gut microbiome: diagnostic and therapeutic potential for rheumatoid arthritis.肠道微生物群的免疫调节特性：类风湿性关节炎的诊断和治疗潜力
Clin Exp Med. 2025 Jul 1;25(1):226. doi: 10.1007/s10238-025-01777-x.
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The interplay between gut microbiome and physical exercise in athletes.运动员的肠道微生物组与体育锻炼之间的相互作用。
Curr Opin Clin Nutr Metab Care. 2024 Sep 1;27(5):428-433. doi: 10.1097/MCO.0000000000001056. Epub 2024 Jul 18.
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Medication adherence in rheumatoid arthritis: implications for cardiovascular disease risk and strategies to address in U.S. veterans.类风湿关节炎患者的药物依从性：对美国退伍军人心血管疾病风险的影响及应对策略
Expert Rev Pharmacoecon Outcomes Res. 2025 Apr;25(4):473-485. doi: 10.1080/14737167.2025.2451141. Epub 2025 Jan 20.
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HDAC/NF-κB signaling pathway mediates gut microbiota dysbiosis in rheumatoid arthritis: Intervention mechanisms of Fengshining decoction.HDAC/NF-κB信号通路介导类风湿关节炎中的肠道微生物群失调：风湿宁汤的干预机制
Phytomedicine. 2025 Sep;145:156976. doi: 10.1016/j.phymed.2025.156976. Epub 2025 Jun 16.
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Genome-scale metabolic modelling of human gut microbes to inform rational community design.人类肠道微生物的基因组规模代谢建模，为合理的群落设计提供信息。
Gut Microbes. 2025 Dec;17(1):2534673. doi: 10.1080/19490976.2025.2534673. Epub 2025 Jul 20.
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Exploring the gut microbiome's influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies.探索肠道微生物群对癌症相关性贫血的影响：机制、临床挑战及创新疗法。
World J Gastrointest Pharmacol Ther. 2025 Jun 5;16(2):105375. doi: 10.4292/wjgpt.v16.i2.105375.
本文引用的文献
1
SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.SIMMER 采用相似性算法来准确识别人类肠道微生物物种和能够进行已知化学转化的酶。
Elife. 2023 Jun 12;12:e82401. doi: 10.7554/eLife.82401.
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Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis.口腔黏膜破损可引发类风湿关节炎患者抗瓜氨酸化细菌和人体蛋白抗体应答。
Sci Transl Med. 2023 Feb 22;15(684):eabq8476. doi: 10.1126/scitranslmed.abq8476.
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participates in the therapeutic effect of methotrexate on arthritis through metabolite regulation.通过代谢物调节参与甲氨蝶呤对关节炎的治疗作用。
Front Microbiol. 2022 Dec 15;13:1015130. doi: 10.3389/fmicb.2022.1015130. eCollection 2022.
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Therapeutic Effects of Butyrate on Pediatric Obesity: A Randomized Clinical Trial.丁酸盐对小儿肥胖的治疗作用：一项随机临床试验。
JAMA Netw Open. 2022 Dec 1;5(12):e2244912. doi: 10.1001/jamanetworkopen.2022.44912.
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Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of .来自类风湿关节炎风险个体的克隆 IgA 和 IgG 自身抗体可识别出一种致关节炎的 菌株。
Sci Transl Med. 2022 Oct 26;14(668):eabn5166. doi: 10.1126/scitranslmed.abn5166.
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Intestinal butyrate-metabolizing species contribute to autoantibody production and bone erosion in rheumatoid arthritis.肠道丁酸代谢物种有助于类风湿关节炎的自身抗体产生和骨侵蚀。
Sci Adv. 2022 Feb 11;8(6):eabm1511. doi: 10.1126/sciadv.abm1511.
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Gut Microbiota-Medication Interaction in Rheumatic Diseases.肠道微生物群-药物相互作用在风湿性疾病中的研究进展
Front Immunol. 2021 Dec 3;12:796865. doi: 10.3389/fimmu.2021.796865. eCollection 2021.
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The gut-joint axis in rheumatoid arthritis.类风湿关节炎的肠-关节轴。
Nat Rev Rheumatol. 2021 Apr;17(4):224-237. doi: 10.1038/s41584-021-00585-3. Epub 2021 Mar 5.
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Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.甲氨蝶呤影响多种人类肠道细菌中保守的途径，导致宿主免疫激活减少。
Cell Host Microbe. 2021 Mar 10;29(3):362-377.e11. doi: 10.1016/j.chom.2020.12.008. Epub 2021 Jan 12.
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The Pretreatment Gut Microbiome Is Associated With Lack of Response to Methotrexate in New-Onset Rheumatoid Arthritis.预处理肠道微生物组与新诊断类风湿关节炎患者对甲氨蝶呤无反应相关。
Arthritis Rheumatol. 2021 Jun;73(6):931-942. doi: 10.1002/art.41622. Epub 2021 May 2.
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