Yoon Yeo Jun, Kim Su Hong, Jeong Seong Ho, Park Chan Wook, Lee Hye Sun, Lee Phil Hyu, Kim Yun Joong, Sohn Young H, Jeong Yong, Chung Seok Jong
Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea.
Department of Radiology, Yeungnam University College of Medicine, Daegu, South Korea.
NPJ Parkinsons Dis. 2024 Nov 17;10(1):221. doi: 10.1038/s41531-024-00834-8.
Individual variability exists in parkinsonian motor symptoms despite a similar degree of nigrostriatal dopamine depletion in Parkinson's disease (PD), called motor reserve. We enrolled 397 patients newly diagnosed with PD who underwent dual-phase F-FP-CIT PET upon initial assessment. Individual motor reserve was estimated based on initial parkinsonian motor symptoms and striatal dopamine transporter availability using a residual model. Patients with low motor reserve (the lowest quartile group, n = 100) exhibited decreased uptake in the occipital region compared to those with high motor reserve (the highest quartile group, n = 100) on early-phase F-FP-CIT PET images. Patients with high motor reserve had a lower risk of conversion to dementia than the those with low motor reserve, whereas the effect of PD groups on the risk of dementia conversion was not mediated by occipital hypoperfusion. These findings suggest that cerebral hypoperfusion in the occipital region is associated with low motor reserve in patients with PD.
尽管帕金森病（PD）患者黑质纹状体多巴胺耗竭程度相似，但帕金森病运动症状仍存在个体差异，这被称为运动储备。我们纳入了397例新诊断为PD的患者，这些患者在初次评估时接受了双相F-FP-CIT PET检查。使用残差模型根据初始帕金森病运动症状和纹状体多巴胺转运体可用性估计个体运动储备。在早期F-FP-CIT PET图像上，运动储备低的患者（最低四分位数组，n = 100）与运动储备高的患者（最高四分位数组，n = 100）相比，枕叶区域摄取减少。运动储备高的患者转化为痴呆的风险低于运动储备低的患者，而PD组对痴呆转化风险的影响并非由枕叶灌注不足介导。这些发现表明，枕叶区域的脑灌注不足与PD患者的低运动储备有关。
