Kircik Leon, Tan Jerry, Lain Edward Ted, Beleznay Katie, Chavda Rajeev, Lachmann Nadège, Brinkhuizen Tjinta, Baldwin Hilary, Layton Alison M
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
University of Western Ontario, Windsor, ON, Canada.
Int J Dermatol. 2025 Apr;64(4):637-646. doi: 10.1111/ijd.17546. Epub 2024 Nov 17.
Acne and sensitive skin can take a profound toll on patients' well-being, which can be exacerbated if the conditions are experienced together. This narrative review aims to identify appropriate treatments to facilitate a holistic management approach to acne (One Acne™), sensitive skin, and acne-induced sequelae and describe the role of treatments in improving skin quality. Topical retinoids are considered the preferred first-line option for acne treatment by dermatologists, either as monotherapy or in combination with other treatments, because of their ability to target various aspects of the disease. Tretinoin, trifarotene, adapalene, and tazarotene have all been assessed in clinical studies for managing acne-associated scarring, with varying success, with the latter three reported to improve skin quality. Moreover, some corrective procedures, e.g., injectable non-animal stabilized hyaluronic acid (NASHA) fillers, have proven effective for treating acne scarring. Both treatment types may complement each other to provide optimal treatment outcomes and patient satisfaction, as observed in several patients receiving concomitant treatment with NASHA fillers/topical trifarotene. Adjunctive use of cleansers, moisturizers, and photoprotection-containing ingredients such as vitamin B3, glycerin, or pro-vitamin B3 may also complement drug/corrective treatments to reduce skin irritation and risk of scarring, as well as improve skin hydration, tone, and overall appearance. This narrative review highlights that comprehensive skincare regimens should be used throughout acne patients' journeys to reduce treatment-related irritation, improve treatment outcomes, adherence, and satisfaction, and enhance overall skin quality. Patients with sensitive skin should choose tailored skincare products to maintain skin barrier integrity and restore skin function.
痤疮和敏感性皮肤会对患者的健康造成严重影响，如果这两种情况同时出现，影响会加剧。本叙述性综述旨在确定合适的治疗方法，以促进对痤疮（One Acne™）、敏感性皮肤和痤疮引发后遗症的整体管理，并描述这些治疗方法在改善皮肤质量方面的作用。由于能够针对痤疮疾病的各个方面，外用维甲酸类药物被皮肤科医生视为痤疮治疗的首选一线选择，可单独使用或与其他治疗方法联合使用。维甲酸、曲法罗汀、阿达帕林和他扎罗汀均已在临床研究中评估用于治疗痤疮相关瘢痕，效果各异，后三种药物据报道可改善皮肤质量。此外，一些矫正程序，如注射用非动物稳定化透明质酸（NASHA）填充剂，已被证明对治疗痤疮瘢痕有效。正如在一些同时接受NASHA填充剂/外用曲法罗汀治疗的患者中观察到的那样，这两种治疗类型可能相互补充，以提供最佳治疗效果和患者满意度。辅助使用清洁剂、保湿剂以及含有光保护成分（如维生素B3、甘油或维生素原B3）也可能补充药物/矫正治疗，以减少皮肤刺激和瘢痕形成风险，以及改善皮肤水合作用、肤色和整体外观。本叙述性综述强调，在痤疮患者的整个治疗过程中应采用全面的护肤方案，以减少治疗相关刺激，改善治疗效果、依从性和满意度，并提高整体皮肤质量。敏感性皮肤患者应选择量身定制的护肤产品，以维持皮肤屏障完整性并恢复皮肤功能。
