Liu Chuan, Xu Huijuan, Wang Peng, Li Yafan, Yi Xiangrui, Tu Ya
School of Food and Bioengineering, Xihua University, Chengdu, P. R. China.
Experimental Research Center, China Academy of Traditional Chinese Medicine, Beijing, P. R. China.
Chem Biodivers. 2025 Apr;22(4):e202402272. doi: 10.1002/cbdv.202402272. Epub 2024 Dec 26.
Traditional herbal medicines, containing syringin in different parts of the world, have been used to enhance memory, relieve pain, cough, clear fever, treat psoas tension, tonsillitis, sore throat, acute gastroenteritis, and anti-inflammatory, analgesic, and so on. In this article, the extraction, analytical method, pharmacological action, and research progress of syringin-containing plants were reviewed. Various extraction methods and detection methods of syringin were summarized, especially the ultrasonic-assisted extraction and high-performance liquid chromatography, which were recommended for the extraction and determination of syringin. We spotlighted the anti-cancer, brain-protective, and anti-inflammatory pharmacological effects of syringin. An in-depth analysis of four plants contains syringin-Eleutherococcus senticosus, Codonopsis pilosula, Daphne tangutica Maxim, and Syringa reticulata subsp. amurensis. In addition, the safety and efficacy of these four plants and preparations containing syringin (Shugan Jieyu Capsule, compound Coginseng tablet, hyoscyamine ointment, and Qinfenghong Zhike capsule) were analyzed. Although syringin has been widely used in traditional medicine, its specific mechanism of action and clinical efficacy are still not completely understood, and further research is needed to explore and verify it. This study provides a valuable theoretical basis and potential research direction for the research and development of new drugs such as anti-cancer and brain protection.
世界各地含有紫丁香苷的传统草药已被用于增强记忆力、缓解疼痛、止咳、清热、治疗腰肌劳损、扁桃体炎、喉咙痛、急性肠胃炎以及抗炎、止痛等。本文综述了含紫丁香苷植物的提取、分析方法、药理作用及研究进展。总结了紫丁香苷的各种提取方法和检测方法，尤其推荐超声辅助提取法和高效液相色谱法用于紫丁香苷的提取和测定。我们重点介绍了紫丁香苷的抗癌、脑保护和抗炎药理作用。深入分析了四种含紫丁香苷的植物——刺五加、党参、唐古特瑞香和暴马丁香。此外，还分析了这四种植物以及含紫丁香苷制剂（疏肝解郁胶囊、复方刺参片、莨菪膏和芩酚红止咳胶囊）的安全性和有效性。尽管紫丁香苷已在传统医学中广泛应用，但其具体作用机制和临床疗效仍不完全清楚，需要进一步研究探索和验证。本研究为抗癌和脑保护等新药研发提供了有价值的理论依据和潜在研究方向。
