Syringin: Plant Source, Traditional Uses, Anti-Cancer, Brain Protection, and Related Pharmacological Properties.

Traditional herbal medicines, containing syringin in different parts of the world, have been used to enhance memory, relieve pain, cough, clear fever, treat psoas tension, tonsillitis, sore throat, acute gastroenteritis, and anti-inflammatory, analgesic, and so on. In this article, the extraction, analytical method, pharmacological action, and research progress of syringin-containing plants were reviewed. Various extraction methods and detection methods of syringin were summarized, especially the ultrasonic-assisted extraction and high-performance liquid chromatography, which were recommended for the extraction and determination of syringin. We spotlighted the anti-cancer, brain-protective, and anti-inflammatory pharmacological effects of syringin. An in-depth analysis of four plants contains syringin-Eleutherococcus senticosus, Codonopsis pilosula, Daphne tangutica Maxim, and Syringa reticulata subsp. amurensis. In addition, the safety and efficacy of these four plants and preparations containing syringin (Shugan Jieyu Capsule, compound Coginseng tablet, hyoscyamine ointment, and Qinfenghong Zhike capsule) were analyzed. Although syringin has been widely used in traditional medicine, its specific mechanism of action and clinical efficacy are still not completely understood, and further research is needed to explore and verify it. This study provides a valuable theoretical basis and potential research direction for the research and development of new drugs such as anti-cancer and brain protection.