Zeng Daofu, Umar Muhammad, Zhu Zhenglin, Pan Haobo, Lu William W, Xiao Guozhi, Chen Yan, Tong Liping, Chen Di
Department of Bone and Joint Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China.
Research Center for Computer-aided Drug Discovery, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China.
Genes Dis. 2024 Feb 24;12(1):101247. doi: 10.1016/j.gendis.2024.101247. eCollection 2025 Jan.
Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development. Among these risk factors, alterations of mechanical loading in the joint leading to changes in biological signaling pathways have been known as a key event in OA development. The importance of AMPK-β-catenin-Runx2 signaling in the initiation and progression of OA has been recognized in recent years. In this review, we discuss the recent progress in understanding the role of this signaling pathway and the underlying interaction mechanisms during OA development. We also discuss the drug development aiming to target this signaling pathway for OA treatment.
骨关节炎（OA）是一种使人衰弱的慢性关节疾病，影响着大量患者，尤其是老年人。OA的病理机制目前尚不清楚。OA的发展涉及多种风险因素。在这些风险因素中，关节机械负荷的改变导致生物信号通路的变化，这被认为是OA发展中的关键事件。近年来，AMPK-β-连环蛋白-Runx2信号在OA发生和发展中的重要性已得到认可。在本综述中，我们讨论了在理解该信号通路在OA发展过程中的作用及其潜在相互作用机制方面的最新进展。我们还讨论了旨在靶向该信号通路进行OA治疗的药物研发情况。
