Jin Zheng, Zhu Zhenhua, Chen Jun, Jing Xiaopeng, Tan Jie, Zeng Ji
Department of Clinical Laboratory, Wuhan Fourth Hospital, Wuhan, China.
Department of Joint Surgery, Wuhan Fourth Hospital, Wuhan, China.
Front Cell Dev Biol. 2025 Aug 22;13:1665313. doi: 10.3389/fcell.2025.1665313. eCollection 2025.
Osteoarthritis (OA) is the most widespread joint disorder worldwide. It is a major cause of lower limb mobility issues in the elderly. With the ongoing aging of the global population and the increasing prevalence of obesity, the disease burden associated with OA is expected to rise significantly. E3 ubiquitin ligases (E3s) play a crucial role in protein ubiquitination. They identify specific substrates and attach ubiquitin molecules to substrates, thus modulating protein stability, function, and cellular localization. E3s can be classified into three main types: RING-, HECT-, and RBR-type E3s. Growing evidence indicates that E3s affect OA by regulating the degradation of extracellular matrix (ECM) proteins and inflammatory responses. This review highlights the functions and underlying mechanisms of E3s in OA, aiming to provide new therapeutic insights for the treatment of OA.
骨关节炎（OA）是全球最普遍的关节疾病。它是老年人下肢活动问题的主要原因。随着全球人口老龄化的持续以及肥胖患病率的上升，与OA相关的疾病负担预计将显著增加。E3泛素连接酶（E3s）在蛋白质泛素化过程中起关键作用。它们识别特定底物并将泛素分子附着到底物上，从而调节蛋白质的稳定性、功能和细胞定位。E3s可分为三种主要类型：RING型、HECT型和RBR型E3s。越来越多的证据表明，E3s通过调节细胞外基质（ECM）蛋白的降解和炎症反应来影响OA。本综述重点介绍了E3s在OA中的功能及潜在机制，旨在为OA的治疗提供新的治疗思路。
