Dahiya Mansi, Dhawan Pankaj, Rani Sapna, Saxena Vidushi
Department of Prosthodontics, Manav Rachna Dental College, Faridabad, IND.
Department of Prosthodontics and Implantology, Manav Rachna Dental College, Faridabad, IND.
Cureus. 2024 Oct 15;16(10):e71506. doi: 10.7759/cureus.71506. eCollection 2024 Oct.
The overview was carried out to evaluate the impact of antiresorptive drug (ARD) therapy in patients undergoing dental implant treatment who significantly experience medication-related osteonecrosis of the jaw (MRONJ) or not. A comprehensive electronic database search within the timeline of 2014-2024, restricted to the English language, was performed in database search engines like Google Scholar, Web of Science, PubMed, and Scopus. The articles were screened using the specific Medical Subject Headings (MeSH) terms and Boolean operators 'OR' and 'AND'. Studies with patients having a history of ARD before, during, or following implant placement were included in the systematic review, without or with meta-analysis. The AMSTAR 2 (A MeaSurement Tool to Assess systematic Reviews) tool was utilized to evaluate the quality of the papers. This review was registered in the International Prospective Register of Systematic Reviews (PROSPERO) database (CRD42024583017). There were 10 systematic reviews as per eligibility criteria. The total number of failed implants was 524, out of which the incidence of MRONJ was between the ranges of 2% and 17%. According to the AMSTAR 2 tool, 20% of the studies were rated as medium quality, 60% were rated as low quality, and 20% were rated as critically low quality. Three meta-analyses were observed for the event "MRONJ," and it found no statistically significant differences between dental implant users with ARD and non-ARD participants. The corroborative evidence presents that patients undergoing dental implants with ARD history significantly experience MRONJ if there is a lack of strategic planning of implant placement.
本综述旨在评估抗吸收药物（ARD）治疗对接受牙种植治疗的患者的影响，这些患者是否显著经历与药物相关的颌骨坏死（MRONJ）。在2014年至2024年的时间范围内，在谷歌学术、科学网、PubMed和Scopus等数据库搜索引擎中进行了全面的电子数据库搜索，仅限于英语。使用特定的医学主题词（MeSH）术语以及布尔运算符“OR”和“AND”对文章进行筛选。纳入系统评价的研究对象为在种植体植入前、期间或之后有ARD病史的患者，有无荟萃分析均可。使用AMSTAR 2（一种评估系统评价的测量工具）工具来评估论文的质量。本综述已在国际系统评价前瞻性注册库（PROSPERO）数据库（CRD42024583017）中注册。根据纳入标准，有10项系统评价。种植失败的总数为524例，其中MRONJ的发生率在2%至17%之间。根据AMSTAR 2工具，20%的研究被评为中等质量，60%被评为低质量，20%被评为极低质量。对“MRONJ”事件进行了三项荟萃分析，发现使用ARD的牙种植患者与未使用ARD的参与者之间没有统计学上的显著差异。确凿证据表明，如果在种植体植入时缺乏战略规划，有ARD病史的牙种植患者会显著经历MRONJ。
