存在非5-HT2型5-羟色胺受体介导兔离体基底动脉收缩的证据。
Evidence for the existence of 5-hydroxytryptamine receptors, which are not of the 5-HT2 type, mediating contraction of rabbit isolated basilar artery.
作者信息
Bradley P B, Humphrey P P, Williams R H
出版信息
Br J Pharmacol. 1986 Jan;87(1):3-4. doi: 10.1111/j.1476-5381.1986.tb10149.x.
Abstract
In the rabbit isolated basilar artery the contractile action of 5-hydroxytryptamine (5-HT) was little affected by high concentrations of ketanserin (1.0 X 10(-6) M) indicating that 5-HT-receptors other than those of the 5-HT2-type were involved. The contractile action of 5-HT was mimicked by methysergide and 5-carboxamidotryptamine (5-CT) with equipotent concentration ratios (5-HT = 1) of about 22 and 0.6 respectively. This profile is characteristic of that in the dog saphenous vein which contains a 5-HT receptor type that may be described as '5-HT1-like'.
摘要
在兔离体基底动脉中，高浓度的酮色林（1.0×10⁻⁶ M）对5-羟色胺（5-HT）的收缩作用影响很小，这表明参与作用的是5-HT2型以外的5-HT受体。5-HT的收缩作用可被麦角新碱和5-羧酰胺色胺（5-CT）模拟，其等效浓度比（5-HT = 1）分别约为22和0.6。这种情况是犬隐静脉中所特有的，犬隐静脉含有一种可被描述为“类5-HT1”的5-HT受体类型。
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